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Table 4 Differential predicted Metacyc pathways abundance associated organophosphorus pesticides (N = 190)

From: Ambient long-term exposure to organophosphorus pesticides and the human gut microbiome: an observational study

Metacyc Pathway

Log2 FC

SE

Adj P

Pyrimidine deoxyribonucleotides de novo biosynthesis IV

0.40

0.12

1.626E-02

Methanogenesis from acetate

0.40

0.12

9.864E-03

Pyrimidine deoxyribonucleotides biosynthesis from CTP

0.37

0.11

1.513E-02

Teichoic acid (poly-glycerol) biosynthesis

0.37

0.09

2.158E-03

dTDP-N-acetylthomosamine biosynthesis

0.36

0.12

3.302E-02

Fucose degradation

0.33

0.09

3.398E-03

L-valine degradation I

0.26

0.06

1.046E-04

Superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation

0.26

0.06

1.150E-03

Superpathway of L-alanine biosynthesis

0.24

0.08

3.529E-02

Sucrose degradation III (sucrose invertase)

0.21

0.06

1.843E-02

Acetylene degradation

0.20

0.06

2.007E-02

Peptidoglycan maturation (meso-diaminopimelate containing)

0.20

0.07

3.053E-02

Superpathway of pyrimidine deoxyribonucleosides degradation

0.19

0.05

8.221E-03

Superpathway of purine deoxyribonucleosides degradation

0.19

0.06

1.909E-02

Purine ribonucleosides degradation

0.17

0.06

4.512E-02

L-lysine biosynthesis I

0.14

0.04

1.453E-02

Galactose degradation I (Leloir pathway)

0.13

0.04

3.328E-02

Pyruvate fermentation to isobutanol (engineered)

0.11

0.04

3.302E-02

L-lysine biosynthesis VI

0.10

0.03

4.718E-02

Calvin-Benson-Bassham cycle

0.09

0.03

4.892E-02

Superpathway of thiamin diphosphate biosynthesis II

-0.23

0.08

3.390E-02

Chitin derivatives degradation

-0.34

0.04

4.191E-14

Creatinine degradation II

-0.36

0.05

1.233E-12

Superpathway of histidine, purine, and pyrimidine biosynthesis

-0.37

0.11

1.215E-02

Superpathway of pyridoxal 5'-phosphate biosynthesis and salvage

-0.39

0.13

3.378E-02

Pyridoxal 5'-phosphate biosynthesis I

-0.41

0.14

3.959E-02

Isoprene biosynthesis II (engineered)

-0.45

0.02

2.081E-146

4-aminobutanoate degradation V

-0.51

0.14

5.027E-03

Ubiquinol-7 biosynthesis (prokaryotic)

-0.71

0.25

4.830E-02

Ubiquinol-9 biosynthesis (prokaryotic)

-0.71

0.25

4.830E-02

Ubiquinol-10 biosynthesis (prokaryotic)

-0.71

0.25

4.830E-02

Ubiquinol-8 biosynthesis (prokaryotic)

-0.71

0.25

4.830E-02

Superpathway of ubiquinol-8 biosynthesis (prokaryotic)

-0.72

0.25

4.505E-02

Formaldehyde assimilation I (serine pathway)

-0.94

0.04

1.613E-132

  1. Model was adjusted for sex, minority status, age, Parkinson's disease status, pesticide co-exposure, and sequencing platform
  2. Abbreviations: Log2FC Log2 Fold Change, SE Standard Error, Adj Adjusted