Kriged and modeled ambient air levels of benzene in an urban environment: an exposure assessment study
© Whitworth et al; licensee BioMed Central Ltd. 2011
Received: 14 September 2010
Accepted: 21 March 2011
Published: 21 March 2011
There is increasing concern regarding the potential adverse health effects of air pollution, particularly hazardous air pollutants (HAPs). However, quantifying exposure to these pollutants is problematic.
Our goal was to explore the utility of kriging, a spatial interpolation method, for exposure assessment in epidemiologic studies of HAPs. We used benzene as an example and compared census tract-level kriged predictions to estimates obtained from the 1999 U.S. EPA National Air Toxics Assessment (NATA), Assessment System for Population Exposure Nationwide (ASPEN) model.
Kriged predictions were generated for 649 census tracts in Harris County, Texas using estimates of annual benzene air concentrations from 17 monitoring sites operating in Harris and surrounding counties from 1998 to 2000. Year 1999 ASPEN modeled estimates were also obtained for each census tract. Spearman rank correlation analyses were performed on the modeled and kriged benzene levels. Weighted kappa statistics were computed to assess agreement between discretized kriged and modeled estimates of ambient air levels of benzene.
There was modest correlation between the predicted and modeled values across census tracts. Overall, 56.2%, 40.7%, 31.5% and 28.2% of census tracts were classified as having 'low', 'medium-low', 'medium-high' and 'high' ambient air levels of benzene, respectively, comparing predicted and modeled benzene levels. The weighted kappa statistic was 0.26 (95% confidence interval (CI) = 0.20, 0.31), indicating poor agreement between the two methods.
There was a lack of concordance between predicted and modeled ambient air levels of benzene. Applying methods of spatial interpolation for assessing exposure to ambient air pollutants in health effect studies is hindered by the placement and number of existing stationary monitors collecting HAP data. Routine monitoring needs to be expanded if we are to use these data to better assess environmental health risks in the future.
Historically, there has been concern regarding the potential adverse human health effects of ozone, sulfur dioxide, nitrogen oxides, carbon monoxide, particulates, and lead. In 1971, the Clean Air Act was established under which National Ambient Air Quality Standards (NAAQS) were created to regulate ambient air concentrations of these six criteria pollutants . A decline in ambient air concentrations of criteria pollutants has been observed since the induction of this Act , and more recently, the focus has shifted to hazardous air pollutants (HAPs), a class of 189 compounds, which are known or suspected to have adverse effects on health . One HAP, benzene, is of particular concern due to its ubiquitous nature and ability to cause cancer in humans . Although the general population is exposed to background levels of benzene, one of the major outdoor sources of personal exposure is vehicular exhaust; additionally, people living near chemical manufacturing facilities or oil refineries may also be exposed to elevated levels of benzene .
The potential for human exposure to benzene is well established, but quantifying exposure for population-based epidemiologic studies is problematic and requires immense resources. For this reason, researchers studying the health effects of ambient air levels of benzene often rely on proxy measures of exposure. One potential source of data is routine monitoring data. Tools like geographic information systems (GIS) and spatial interpolation methods such as kriging have helped to utilize these data to estimate levels of ambient air pollutants at unmeasured locations. Previous studies that have used kriging to map air pollution levels include: sulfur dioxide in Instanbul, Turkey , ozone in Atlanta [6, 7] and northern Georgia , and particulates across the entire U.S.  and in Beijing, China . Kriging has also been used in a range of epidemiologic studies of criteria pollutants to examine exposures to NO2 among pregnant women in Spain  as well as associations between: particulates and ozone and mortality in Los Angeles , particulates and mortality in Hamilton, Ontario, Canada , particulates and ectopy in the U.S. , CO, NO2, CO2 and preterm birth in Korea , ozone and pediatric asthma exacerbation in Atlanta , and particulates and low birth weight in Korea .
Although kriging appears to have become a useful tool in studies of criteria pollutants, in part because of the availability of monitoring data due to regulatory requirements, a limited number of studies have applied these methods to HAPs. Several studies have used kriging in the exposure assessment of ambient air levels of radon [16–18], but fewer investigations have applied this method to volatile organic compounds (VOCs). Following an extensive ambient air monitoring campaign that was conducted over a two-week period, Miller et al.  recently applied ordinary kriging to examine the spatial variability of total VOCs and BTEX (benzene, toluene, ethylbenzene and xylene, combined) in Detroit, Michigan (U.S.) and Windsor, Ontario (Canada). However, the usefulness of kriging to predict annual benzene levels using routine monitoring data, as might be needed in epidemiologic studies of health effects such as cancer, has not been fully explored. In contrast, data from the Assessment System for Population Exposure Nationwide (ASPEN) model, generated from the U.S. EPA has been applied in epidemiologic studies. Previously, for example, we conducted a study of childhood cancer in the Houston metropolitan area that used the ASPEN modeled estimates in the exposure assessment and found increased rates of childhood leukemia among census tracts with the highest levels of benzene . Harris County, in which Houston is located, is home to a large number of petrochemical industries and is the fourth largest metropolitan area of the U.S., with a dense network of roadways. It is also one of the most closely monitored cities in the nation . Given our previous epidemiologic finding, and in light of the fact that the ASPEN modeled estimates are only available for select years, we were interested in whether existing monitoring data could be used to provide additional information regarding exposure assessment of benzene. Hence, we conducted a study to apply kriging to predict ambient air levels of benzene for the years 1998 to 2000 at unmonitored locations in Harris County and to assess the degree of correspondence between the census tract-level kriged benzene levels and estimates of benzene obtained from the ASPEN model.
The modeled data used in this analysis were from the 1999 U.S. EPA NATA project, which was undertaken to evaluate air toxics across the U.S . As stated by the U.S. EPA, two uses of this assessment are to "provide a starting point for local-scale assessment" and to "inform monitoring programs" . In 1999, NATA used the ASPEN model, a complex dispersion model, to estimate annual average concentrations of benzene and 176 other HAPs for each census tract in the contiguous U.S. and Puerto Rico. The 1999 ASPEN model incorporated meteorologic data, emissions data, and determinants of ambient air pollutant concentrations such as: rate, location and height of release, reactive decay, deposition, and secondary formation . The 1999 ASPEN model also incorporated monitoring data to estimate the background concentrations (i.e., ambient air concentrations that result from emissions from natural sources, long-term transport from sources more than 50 km away, and emissions from unknown sources) .
Kriging is a statistical technique developed in geostatistics for optimal spatial prediction at unobserved locations . Kriging requires that the parameters of a theoretical semivariogram function, which describe the spatial autocorrelation structure, be estimated from observed data and then uses information from observations at nearby locations along with the spatial structure to interpolate levels at unmonitored locations. The semivariogram is characterized by three parameters: the nugget effect, the sill, and the range. The nugget is the value of the semivariogram function at a distance of zero, the sill is the value at which the semivariogram levels off, and the range is the distance that corresponds to the sill. The difference between the sill and the nugget is often referred to as the partial sill.
In Equation 1, h is the distance between monitoring sites and θ = (c0, cs, αs)' where c0 represents the nugget effect(c0 ≥ 0), cs represents the partial sill (sill minus the nugget effect)(cs ≥ 0), and αs represents the range (αs ≥ 0).
For both kriging models, we fit the theoretical semivariogram using nonlinear regression and, with the monitoring data from the 17 monitors in Harris, Brazoria, and Galveston Counties, used the model estimates to generate kriged values for each of the 649 census tracts in Harris County. Because three monitoring sites in Harris County were not in operation for all three years (one site was not operative in 2000, one site was not operative in 1998, and one site was not operative in 1998 or 1999), there were a total of 47 data points used for the kriging analysis. The parameter estimates of the trend obtained from the universal kriging model did not differ significantly from zero and similar results were obtained under both models (e.g., the mean, median, and mean standard error of the kriged benzene values were 0.745 ppbV, 0.741, and 0.354 ppbV for ordinary kriging and 0.757 ppbV, 0.759, and 0.383 ppbV for universal kriging, respectively). Moreover, we detected no difference in the residuals from the universal and ordinary kriging models using a Bland-Altman analysis  (results not shown). Because none of these results provided evidence of non-stationarity, we conducted all further analyses using the ordinary kriging model and report those results herein.
We performed two additional analyses. First, to determine how using the larger monitoring network for the variogram selection might affect the kriging results, we conducted a sensitivity analysis that relied upon the complete network of 55 monitors to predict benzene levels in Harris County and compared the kriged values from this analysis to those values using the original network of 17 monitors from Harris, Galveston, and Brazoria Counties. Secondly, to evaluate the impact of using a monitoring network that is spread across a relatively large geographic area, we stratified the results according to the distance of the census tract centroid from the individual monitoring sites. If the centroid of the census tracts was within 5 miles of a monitoring site, then the census tract was classified as "near"; if the census tract centroid was farther than 5 miles from a monitoring site, then the census tract was classified as "far". This stratification resulted in 281 "near" census tracts and 368 "far" census tracts. We implemented a z-test to formally compare the kappa statistics generated for these two groups.
Comparative analysis of kriged and modeled benzene levels
The non-parametric Kolmogorov-Smirnov two-sample test  was used to compare the empirical cumulative distribution functions for the two sets of benzene air levels (kriged predictions and ASPEN estimates). We also estimated the Spearman rank correlation coefficient between the kriged predictions and ASPEN estimates for the 649 census tracts in Harris County. We further categorized the data into quartiles (ASPEN estimates: ≤ 0.509 ppbV, 0.510 ppbV - 0.618 ppbV, 0.619 ppbV - 0.835 ppbV, ≥ 0.836 ppbV; kriged predictions: ≤ 0.678 ppbV, 0.679 ppbV - 0.740 ppbV, 0.741 ppbV - 0.814 ppbV, ≥ 0.815 ppbV) and used weighted Kappa statistics to compare the agreement between the discretized levels.
All analyses were conducted in SAS (version 9.1; SAS Institute Inc., Cary, NC).
Distribution of ASPEN and kriged values of benzene levels in 649 Harris County census tracts.
1999 ASPEN Modeled Estimate (ppbV)
1998-2000 Kriged Predicted Value (ppbV)
Quartile classification of benzene levels in 649 Harris County census tracts, kriged values versus ASPEN estimates.
1999 ASPEN Modeled Estimates
1998-2000 Kriged Predicted Values
Low No. (%)
Medium-Low No. (%)
Medium-High No. (%)
High No. (%)
The sensitivity analysis comparing the kriged benzene values using the complete network of all 55 monitors in Texas versus the restricted network of 17 monitors in Harris, Galveston, and Brazoria Counties indicated similar results. The mean ambient benzene level using all 55 monitors was 0.73 (standard deviation (SD) = 0.10) while the mean ambient benzene level using the restricted network was 0.74 (SD = 0.08) and the mean benzene level from the ASPEN model was 0.71 (SD = 0.31). After stratifying by the "near" and "far" groups, the kappa statistic for the "far" census tracts was 0.26 (95% CI = 0.19, 0.33) while the kappa statistic for the "near" census tracts was 0.18 (95% CI = 0.09, 0.27). Although the magnitude of the kappa statistic for the "far" census tracts is greater than that for the "near" census tracts, they were not statistically significantly different (p = 0.3).
Our investigation made comparisons between a complex dispersion model developed by the U.S. EPA (ASPEN model) and a method of spatial interpolation (kriging) using routine monitoring data for benzene, a HAP. Overall, we found a lack of correspondence between kriged benzene predictions and ASPEN modeled estimates. The kriging model that we applied did not use data that could potentially affect variability in ambient benzene levels, including meteorology and source emissions from roadway traffic or industrial sites. The ASPEN model, in contrast, relies on more complex data sources, incorporating not only meteorological and pollutant source data, but also fate and transport data (including information about reactive decay of pollutants, deposition, and secondary formation) and monitoring data to estimate background concentrations of the pollutant of interest . The discrepancies in the input data used by each method may contribute to the discordant results we observed. Although kriging has been used to interpolate ambient air levels of criteria air pollutants in exposure assessment and epidemiologic studies [6, 9, 11–15], few other studies have applied kriging to benzene [19, 32].
The range of predicted benzene values observed in our study is smaller than that estimated from the ASPEN model. This may be due to the fact that kriging is a spatial smoothing tool that provides an optimal average over the region based on sampled observations. We also found poor agreement between the two metrics irrespective of whether the continuous or discretized values were evaluated. While significant, there was only modest correlation between the modeled and predicted values. Based on the quartile analysis, approximately 44% of census tracts classified by the ASPEN model as having the lowest ambient air levels of benzene were classified into a higher category using the predicted kriged results. Similarly, about 72% of census tracts in the highest quartile based on the ASPEN model were classified into lower categories using the kriging metric.
Measurements of ambient air pollutants using standard reference methods represent the optimal data source. Several studies have compared estimates from the ASPEN model to routine monitoring data and found reasonably good agreement between the two for ambient benzene levels [33–35]. Therefore, under the assumption that the ASPEN model yields reasonable estimates of ambient air pollutants at the census tract level, our results suggest that relying on kriged predictions instead would result in extensive misclassification had this exposure metric been used in an epidemiologic study. Although Houston, Texas is considered a closely monitored area , in our study, use of kriging that relies upon routine monitoring data for epidemiologic purposes or exposure assessment is still limited by a low ratio of monitoring sites to total land area. Given that we found similar agreement between the ASPEN modeled estimates and the kriged predictions for census tracts that were within 5 miles of a monitoring site as compared with census tracts further (>5 miles) from one or more monitoring sites, it appears that greater resolution in terms of the number of benzene monitors per area would be required for kriging, as has been suggested recently by the work of Cocheo and colleagues .
There has been success in applying kriging to predict ambient air levels of the criteria pollutants [9, 11–15] which may be due, in part, to the regional nature of some of these pollutants as well as the relatively large monitoring networks utilized by many of these investigations. For example, the networks used in these studies ranged from 23 monitoring sites measuring PM2.5 and 42 ozone sites in the Los Angeles area  to 93 monitors measuring NO2 in Valencia, Spain to an average of 456 sites measuring PM2.5 across the U.S. . Spatial variability over such expansive geographic regions are likely influenced more by meteorological and topographic factors than by specific emission sources and dispersion characteristics .
Another issue that may have affected the lack of agreement observed in the present study is the placement of monitors. Because the monitors are used primarily for regulatory purposes, they are not uniformly spatially located. The majority of the monitors used in our study are located near a large petrochemical complex in Houston (known as the Houston Ship Channel) and largely situated away from major transportation corridors in the county. As a result, the kriging predictions generally do not account for HAP levels arising from mobile sources, which make a significant contribution to ambient air levels of HAPs such as benzene [38, 39]. In a recent study that applied kriging methodology to BTEX and other VOCs , after placement of 100 monitors across two cities in North America, the authors concluded that there was considerable intraurban variability in VOC levels in Detroit, Michigan (U.S.), where emissions of these chemicals are large and from similar sources to those in the greater Houston metropolitan area. Thus, we expect that interpolating ambient air levels of a localized (rather than regional) air pollutant will remain problematic in the absence of additional and more equitably distributed monitors across a geographic locale.
To obtain stable estimates of the theoretical semivariogram function, we used data from all ambient monitors in Texas. We assumed that the underlying spatial correlation between monitoring sites in our study area was similar to that of all monitoring sites in Texas. This is similar to others who have generated semivariograms for ozone and particulates [9, 40] over five regions in the U.S., and for NO2, PM10, and O3 across the European Union . Further, when we conducted a sensitivity analysis comparing the kriged predictions using the complete monitoring network of all Texas monitors versus only the 17 monitoring sites in Harris, Galveston, and Brazoria counties, the results were similar. At the time the present study was conducted, the ASPEN estimates were only available for 1999; thus, we restricted our use of the monitoring data to 1998-2000. Although we considered using only monitoring data from 1999, there were not enough data in this one year to accurately estimate the semivariogram. This is not likely to have introduced much error in our evaluation given that the annual mean benzene levels (mean ± 2SD) using all 55 monitoring sites in Texas for 1998 (N = 46), 1999 (N = 48), and 2000 (N = 46) were: 0.8 ppbV (0.1, 1.4), 0.9 ppbV (0.2, 1.5), and 0.8 (0, 1.6), respectively.
This study compared predicted annual levels of benzene in ambient air to those generated by the ASPEN model to assess the value of kriging in epidemiologic investigations of HAPs. Due to the discrepancies found in these two methods, we feel that until improvements are made regarding the placement and number of monitors collecting HAP data, researchers interested in studying the health effects of these air pollutants must rely on data sources such as the ASPEN modeled estimates or other exposure models and innovative exposure assessment strategies such as generalized additive models or land use regression.
List of Abbreviations
assessment system for population exposure nationwide
air quality system
benzene, toluene, ethylene, and xylene
geographic information systems
hazardous air pollutant
national ambient air quality standards
national air toxics assessment
particulate matter ≤ 10 micrometers in diameter
volatile organic compound
This project was funded by the National Cancer Institute, National Institutes of Health, Department of Health and Human Services through grant #1 R03 CA128106-02.
- Suh HH, Bahadori T, Vallarino J, Spengler JD: Criteria air pollutants and toxic air pollutants. Environ Health Perspect. 2000, 108 (Suppl 4): 625-633. 10.2307/3454398.View Article
- National Research Council: Human exposure assessment for airborne pollutants: advances and opportunities. 1991, National Academy Press
- U.S. EPA: Toxic Air Pollutants, About Air Toxics. 2008, [http://www.epa.gov/air/toxicair/newtoxics.html]
- Agency for Toxic Substance and Disease Registry: Toxicological Profile for Benzene. 2007, [http://www.atsdr.cdc.gov/toxprofiles/tp3.pdf]
- Tayanc M: An assessment of spatial and temporal variation of sulfur dioxide levels over Istanbul, Turkey. Environ Pollut. 2000, 107: 61-69. 10.1016/S0269-7491(99)00131-1.View Article
- Mulholland JA, Butler AJ, Wilkinson JG, Russell AG, Tolbert PE: Temporal and spatial distributions of ozone in Atlanta: regulatory and epidemiologic implications. J Air Waste Manag Assoc. 1998, 48: 418-426.View Article
- Tolbert PE, Mulholland JA, MacIntosh DL, Xu F, Daniels D, Devine OJ, Carlin BP, Klein M, Dorley J, Butler AJ, Nordenberg DF, Frumkin H, Ryan PB, White MC: Air quality and pediatric emergency room visits for asthma in Atlanta, Georgia, USA. Am J Epidemiol. 2000, 151: 798-810.View Article
- Bell ML: The use of ambient air quality modeling to estimate individual and population exposure for human health research: a case study of ozone in the Northern Georgia Region of the United States. Environ Int. 2006, 32: 586-593. 10.1016/j.envint.2006.01.005.View Article
- Liao D, Peuquet DJ, Duan Y, Whitsel EA, Dou J, Smith RL, Lin HM, Chen JC, Heiss G: GIS approaches for the estimation of residential-level ambient PM concentrations. Environ Health Perspect. 2006, 114: 1374-1380. 10.1289/ehp.9169.View Article
- Zhao WH, Gong HL, Zhao WJ, Zhu L, Tang T: Temporal and spatial variation of urban airborne inhalable particle and it's influence factor analysis using GIS & RS. 2009 17th International Conference on Geoinformatics, Geoinformatics 2009: 2009. 2009
- Iniguez C, Ballester F, Estarlich M, Llop S, Fernandez-Patier R, Aguirre-Alfaro A, Esplugues A: Estimation of personal NO2 exposure in a cohort of pregnant women. Science of the Total Environment. 2009, 407: 6093-6099. 10.1016/j.scitotenv.2009.08.006.View Article
- Jerrett M, Burnett RT, Ma R, Pope CA, Krewski D, Newbold KB, Thurston G, Shi Y, Finkelstein N, Calle EE, Thun MJ: Spatial analysis of air pollution and mortality in Los Angeles. Epidemiology. 2005, 16: 727-736. 10.1097/01.ede.0000181630.15826.7d.View Article
- Jerrett M, Buzzelli M, Burnett RT, DeLuca PF: Particulate air pollution, social confounders, and mortality in small areas of an industrial city. Soc Sci Med. 2005, 60: 2845-2863. 10.1016/j.socscimed.2004.11.006.View Article
- Leem JH, Kaplan BM, Shim YK, Pohl HR, Gotway CA, Bullard SM, Rogers JF, Smith MM, Tylenda CA: Exposures to air pollutants during pregnancy and preterm delivery. Environ Health Perspect. 2006, 114: 905-910. 10.1289/ehp.8733.View Article
- Seo JH, Leem JH, Ha EH, Kim OJ, Kim BM, Lee JY, Park HS, Kim HC, Hong YC, Kim YJ: Population-attributable risk of low birthweight related to PM10 pollution in seven Korean cities. Paediatric and Perinatal Epidemiology. 2010, 24: 140-148. 10.1111/j.1365-3016.2009.01085.x.View Article
- Manthena DV, Kadiyala A, Kumar A: Interpolation of radon concentrations using GIS-based kriging and cokriging techniques. Environmental Progress and Sustainable Energy. 2009, 28: 487-492. 10.1002/ep.10407.View Article
- Zhu HC, Charlet JM, Poffijn A: Radon risk mapping in southern Belgium: an application of geostatistical and GIS techniques. Science of the Total Environment. 2001, 272: 203-210. 10.1016/S0048-9697(01)00693-3.View Article
- Franco-Marina F, Villalba-Caloca J, Segovia N, Tavera L: Spatial indoor radon distribution in Mexico City. Science of the Total Environment. 2003, 317: 91-103. 10.1016/S0048-9697(03)00270-5.View Article
- Miller L, Lemke LD, Xu X, Molaroni SM, You H, Wheeler AJ, Booza J, Grgicak-Mannion A, Krajenta R, Graniero P, Krouse H, Lamerato L, Raymond D, Reiners J, Weglicki L: Intra-urban correlation and spatial variability of air toxics across an international airshed in Detroit, Michigan (USA) and Windsor, Ontario (Canada). Atmospheric Environment. 2010, 44: 1162-1174. 10.1016/j.atmosenv.2009.12.030.View Article
- Whitworth KW, Symanski E, Coker AL: Childhood lymphohematopoietic cancer incidence and hazardous air pollutants in southeast Texas, 1995-2004. Environ Health Perspect. 2008, 116: 1576-1580. 10.1289/ehp.11593.View Article
- Texas Commission on Environmental Quality: Texas Commission on Environmental Quality, The Houston Air Quality Challenge. 2006, [http://www.tceq.state.tx.us/comm_exec/forms_pubs/pubs/pd/020/05-02/houston.html]
- U.S. EPA: Technology Transfer Network, 1999 National Air Toxics Assessment. About the 1999 Assessment. 2008, [http://www.epa.gov/ttn/atw/nata1999/aboutassess.html]
- U.S. EPA: Technology Transfer Network Air Toxics Web Site, National Air Toxics Assessments. 2007, [http://www.epa.gov/ttn/atw/natamain/]
- U.S. EPA: Technology Transfer Network, 1999 National Air Toxics Assessment: The ASPEN Model. 2008, [http://www.epa.gov/ttn/atw/nata1999/aspen99.html]
- U.S. EPA: Final technical report on estimated background concentrations for the National-Scale Air Toxics Assessment. 2003, Emissions, Monitoring, and Analysis Division, Office of Air Quality Planning and Standards, [http://www.epa.gov/ttn/atw/nata1999/natabackgroundreport2003.pdf]
- U.S. EPA: Air Quality System (AQS) Monitoring Data. 2007, [http://www.epa.gov/ttn/airs/airsaqs/basic_info.htm]
- McClenny WA, Holdren MW: Compendium Method TO-15, Determination of volatile organic compounds in air collected in specially-prepared canisters and analyzed by gas chromatography/mass spectrometry. 1999, U.S. Environmental Protection Agency: Report EPA/625/r-96/010b
- Waller L: Applied Spatial Statistics for Public Health Data. 2004, Hoboken, NJ: John Wiley & SonsView Article
- Bland JM, Altman DG: Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986, 1: 307-310.View Article
- Gibbons J, Chakraborti S: Nonparametric statistical inference. 2003, New York: Marcel Dekker Ltd
- U.S. EPA: Toxics Release Inventory (TRI) Program. 2007, [http://www.epa.gov/tri/index.htm]
- Miller L, Xu X, Luginaah I: Spatial variability of volatile organic compound concentrations in Sarnia, Ontario, Canada. Journal of toxicology and environmental health Part A. 2009, 72: 610-624. 10.1080/15287390802706413.View Article
- Rosenbaum AS, Axelrad DA, Woodruff TJ, Wei YH, Ligocki MP, Cohen JP: National estimates of outdoor air toxics concentrations. J Air Waste Manag Assoc. 1999, 49: 1138-1152.View Article
- U.S Environmental Protection Agency: Comparison of ASPEN Modeling System Results to Monitored Concentrations: Executive Summary. 2007, [http://www.epa.gov/ttn/atw/nata/mtom_pre.html]
- Lupo PJ, Symanski E: A comparative analysis of modeled and monitored ambient hazardous air pollutants in Texas: a novel approach using concordance correlation. J Air Waste Manag Assoc. 2009, 59: 1278-1286. 10.3155/1047-32188.8.131.528.View Article
- Cocheo C, Sacco P, Ballesta PP, Donato E, Garcia S, Gerboles M, Gombert D, McManus B, Patier RF, Roth C, De Saeger E, Wright E: Evaluation of the best compromise between the urban air quality monitoring resolution by diffusive sampling and resource requirements. Journal of Environmental Monitoring. 2008, 10: 941-950. 10.1039/b806910g.View Article
- Beelen R, Hoek G, Pebesma E, Vienneau D, de Hoogh K, Briggs DJ: Mapping of background air pollution at a fine spatial scale across the European Union. Sci Total Environ. 2009, 407: 1852-1867. 10.1016/j.scitotenv.2008.11.048.View Article
- Parra MA, Elustondo D, Bermejo R, SantamarÃa JM: Ambient air levels of volatile organic compounds (VOC) and nitrogen dioxide (NO2) in a medium size city in Northern Spain. Science of the Total Environment. 2009, 407: 999-1009.
- Wheeler AJ, Smith-Doiron M, Xu X, Gilbert NL, Brook JR: Intra-urban variability of air pollution in Windsor, Ontario--measurement and modeling for human exposure assessment. Environ Res. 2008, 106: 7-16. 10.1016/j.envres.2007.09.004.View Article
- Wong DW, Yuan L, Perlin SA: Comparison of spatial interpolation methods for the estimation of air quality data. J Expo Anal Environ Epidemiol. 2004, 14: 404-415. 10.1038/sj.jea.7500338.View Article
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.