Environmental Health

Table 4 Association of log-transformed HbA1c, FPI and HOMA-IR with log-transformed concentrations of iAs in drinking water and of iAs metabolites in urine, adjusted for age, sex, obesity and hypertension

From: Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico

	HbA1c					FPI		HOMA-IR
	β^a	95% CI		p^b	β^a	95% CI		p^b	β^a	95% CI		p^b
Water iAs	0.193	0.018	0.369	0.03	-2.084	-2.720	-1.448	< 0.01	-1.641	-2.358	-0.924	< 0.01
Urinary tAs	0.164	-0.570	0.898	0.66	-5.313	-8.068	-2.559	< 0.01	-4.538	-7.514	-1.562	< 0.01
Urinary iAs^III	-0.003	-0.075	0.069	0.94	-0.534	-0.803	-0.266	< 0.01	-0.409	-0.698	-0.121	< 0.01
Urinary MAs^III	0.003	-0.031	0.078	0.39	-0.037	-0.608	-0.007	0.02	-0.020	-0.053	0.013	0.25
Urinary DMAs^III	0.023	-0.031	0.078	0.40	-0.404	-0.608	-0.199	< 0.01	-0.301	-0.523	-0.078	< 0.01
Urinary iAs^V	0.008	-0.005	0.021	0.23	-0.028	-0.079	0.023	0.29	-0.041	-0.096	0.014	0.14
Urinary MAs^V	0.007	-0.086	0.100	0.88	-0.421	-0.777	-0.065	0.02	-0.292	-0.670	0.087	0.13
Urinary DMAs^V	0.085	-0.281	0.452	0.65	-1.282	-2.689	0.125	0.07	-0.884	-2.382	0.615	0.25
Urinary DMAs/MAs ratio	0.074	-0.043	0.192	0.22	-0.403	-0.856	0.050	0.08	-0.372	-0.859	0.114	0.13
Urinary MAs/iAs ratio	0.007	-0.016	0.030	0.56	0.092	0.003	0.182	0.04	0.123	0.030	0.216	0.01

Abbreviations: HbA1c, glycated hemoglobin; FPI, fasting plasma insulin; HOMA-IR, homeostasis model assessment - insulin resistance; β, regression coefficient; CI, confidence interval.
^a Units of β and CI are 10 ppb for iAs concentration. Coefficients for metabolites are standardized to an increment of one inter-quartile range.
^b p-value for test of β = 0.

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ISSN: 1476-069X

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