From: PM2.5, oxidant defence and cardiorespiratory health: a review
Study | Design and location | Population | Polymorphism(s)/treatment | Ambient exposure | Outcome(s)g | Main findings/effect estimates |
---|---|---|---|---|---|---|
Cardiovascular outcomes | Â | Â | Â | Â | Â | |
Schwartz et al. 2005 (11)a,h | Normative Aging Study Cohort Boston, US (2000–2004) | 497 Caucasian Men Mean Age: 73 years | GSTM1 | 48-hour average PM2.5 | HF | Change Per 10 μg/m3 GSTM1-present − 3.6% (95% CI: -40.5, 56.2) GSTM1-null − 34% (95% CI: -53, -7.2) |
Chahine et al. 2007 (13)a,h | Normative Aging Study Cohort Boston, USA (2000–2005) | 539 Caucasian Men Mean Age: 73 years | GSTM1 HMOX-1 promoter | 48-hour average PM2.5 | SDNN, HF, LF | Change per 10 μg/m3 GSTM1-present SDNN: -2.0% (95% CI: -11.3, 8.3) HF: -4.0% (95% CI: -24.8, 22.6) LF:-0.6% (95% CI: -19.0, 22.0) GSTM1-null SDNN: -10.5% (95% CI: -18.2, -2.2) HF: -24.2% (95% CI: -39.2, -5.5) LF: -17.0% (95% CI: -31.0, -0.2) HMOX-1 short repeat SDNN: 7.4% (95% CI:-8.7, 26.2) HF: 8.9% (95% CI:-27.1, 62.8) LF: 14.0% (95% CI: -18.6, 59.5) HMOX-1 long repeat SDNN: -8.5% (95% CI: -14.8, -1.8) HF: -20.1% (95% CI: -32.9, -5.0) LF: -14.0% (95% CI: -25.7, -0.5) GSTM1-null and HMOX-1 long repeat SDNN: -12.7% (95% CI: -20.6, -3.9) HF: -27.8% (95% CI: -43.0, -8.5) LF: -20.1% (95% CI: -34.5, -2.7) |
Park et al. 2006 (12)b,h | Prospective Cohort Boston, US (2000–2004) | 518 Caucasian Men Mean Age: 73 years | HFE | 48-hour average PM2.5 | HF LF LF/HF SDNN | Change Per 10 μg/m3 HFE wild type HF: -31.7% (95% CI: -48.1, -10) The authors noted that similar associations were observed for SDNN, LF, and LF/HF but the data was not shown. |
Ren et al. 2010 (15)c,h | Prospective Cohort Boston, US (1995–2006) | 1000 Caucasian Men Mean Age: 72 years | HFE NQO1 CAT GSTM1 GSTP1 GSTT1 HMOX-1 | 7-day PM2.5 moving average | Total plasma homocysteine | Change Per 4.56 μg/m3 HFE wild type 1.81% (95% CI: 0.46, 3.16) HFE-variant (rs1800562) − 2.5% (95% CI: -5.68, 0.68) CAT wild type 0.75% (95% CI: -0.85, 2.35) CAT-variant (rs2300181) 2.84% (95% CI:’.06, 4.62) |
Madrigano et al. 2010 (14)d,h | Prospective Cohort Boston USA (1998–2008) | 809 Caucasian Men Mean Age: 74 years | GSTM1 HMOX-1 HFE | 1-3 day PM2.5 moving average | sICAM-1 sVCAM-1 | Polymorphisms in GSTM1, HMOX-1, or HFE genes did not modify the relationship between PM2.5 exposure and serum concentrations of sICAM-1 or sVCAM-1 (effect estimates not reported) |
Romieu et al. 2005 (31)e | Randomized Double-Blind Trial | 60 Adults Mean Age: 80 years | 2 g/day fish oil or 2 g/day soy oil | Daily Indoor PM2.5 | HF LF pNN50 SDNN rMSSD | Change Per 8 μg/m3 Pre-Supplementation Group (fish oil) Log10 HF: -54% (95% CI: -72, -24) Log10 LF: -48% (95% CI :-69, -15) Log10 pNN50: -44% (95% CI : -56, -27) Log10 SDNN : -27% (95% CI : -37, -16) Log10 rMSSD: -32% (95% CI: -43, -19) Supplementation Phase (fish oil) Log10 HF: -7% (95% CI: -20, 7) Log10 LF: -10% (95% CI : -22, 3) Log10 pNN50: -5% (95% CI: -12, 2) Log10 SDNN: -0.5% (95% CI: -4, 3) Log10 rMSSD: 0.02% (95% CI: -7, 8) |
Respiratory Outcomes | ||||||
Breton et al. 2011 (30)f | Prospective Cohort California, USA (1993–2004) | 2106 Children Mean Age (baseline): 10 years | GSS | Yearly Average PM2.5 | Lung function growth in: FEV1 FVC MMEF | Per 22.2 μg/m3 GSS-H0100000 FEV1: -124 ml (95% CI: -203, -45.3) FVC: -92.9 ml (95% CI: -186, 0.2) MMEF: -193.9 ml/s (95% CI: -352.2, -35.6) Other GSS Haplotypes FEV1: -49 ml (95% CI: -182, 83.9) FVC: -106.8 ml (95% CI: -247, 33.2) MMEF: -70.9 ml/s (95% CI: -309, 167.3) |