Study [reference] (Table from original publication) | Study locale | Outcome | Exposure1[comments] | ICD2 | Outcome measure | Cases | Risk estimate (95% CI) |
---|---|---|---|---|---|---|---|
Chen et al. 19853[24] (Table One) | 84 villages from 4 neighbouring townships on SW coast, Taiwan | Mortality 1968-82 | Median arsenic content of artesian well and (range): 780 μg˙•L-1 (350–1,140); in shallow well: 40 (0.0–300). Period of samples collection not reported. | ICD 189 | SMRmale | 42 | 7.72 (5.37–10.1) |
[Comparison of mortality rate in Blackfoot disease (BFD) with those of the general population.] | SMRfemale | 62 | 11.2 (8.38–14.0) | ||||
* Chen et al. 19884[26] (Table One) | BFD endemic area, Taiwan | Mortality 1973-86 | Arsenic well water concentration (μg˙•L-1). Period of samples collection not reported. | ICD 189 | |||
General population | ASMRmale | – | 1.1 | ||||
– | 5.4 | ||||||
< 300 | – | 13.1 | |||||
300-590 | – | 21.6 | |||||
≥ 600 | |||||||
General population | ASMRfemale | – | 0.9 | ||||
– | 3.6 | ||||||
< 300 | – | 12.5 | |||||
300-590 | – | 33.3 | |||||
≥ 600 | |||||||
[Comparison of mortality rate in BFD with those of the general population.] | |||||||
*Wu et al. 19895[27] (Table Three) | BFD endemic area, Taiwan (42 villages) | Mortality 1973-86 | Arsenic well water concentration (μg˙•L-1) based on well water samples collected between 1964–66. | ICD8 189 | |||
< 300 | ASMRmale | 9 | 8.42 | ||||
11 | 18.9 | ||||||
300–590 | 6 | 25.3 | |||||
≥ 600 | |||||||
< 300 | ASMRfemale | 4 | 3.42 | ||||
13 | 19.4 | ||||||
300–590 | 16 | 58.0 | |||||
≥ 600 | |||||||
Chen and Wang 19906[28] (Table Four) | 314 precincts & townships in Taiwan, including 4 from BFD endemic area | Mortality 1972-83 | Average arsenic levels in water samples of all 314 geographical units. 73.9% had < 5% of wells with > 50 μg˙•L-1 ; 14.7% had 5-14%; 11.5% had ≥ 15%. Well water samples collected between 1974–76. | ICD 189 | |||
All precincts & townships | ASMRmale | – | 1.1 (0.2) | ||||
ASMRfemale | – | 1.7 (0.2) | |||||
Southwestern townships | ASMRmale | – | 1.2 (0.2) | ||||
ASMRfemale | – | 1.7 (0.3) | |||||
Guo et al. 19977[37] (Table Two) | 243 townships in Taiwan | Incidence 1980-87 | Arsenic well water concentration ranging from < 50 to > 640 μg˙•L-1. | ICD 189.0, 189.1 | RDmale | – | 0.03 (0.02) |
Estimate presented measured at > 640 μg˙•L-1. [Arsenic measurements from a National survey of 83,656 wells in 243 townships, collected mostly between 1974–76.] | RDfemale | – | 0.14 (0.013) | ||||
Rivara et al.1997 [38] (Table Four) | Chile | Mortality 1950-92 | Annual average arsenic concentration in drinking water for Antofagasta (Region II of Chile) ranging between 40 to 860 μg˙•L-1. Data from historical records from 1950–1992. | ICD 189 | RR | – | 3.8 (3.1–4.7) |
[Comparison of mortality rate in Region II (exposed) populations vs Region VIII (control population.] | |||||||
Smith et al. 1998 [39] | Chile | Mortality 1989-93 | Region II of Northern Chile with population weighted average arsenic concentration in drinking water up to 569 μg˙•L-1 compared with the rest of Chile; exposure generally < 10 μg˙•L-1. | N/A | SMRmale | 39 | 1.6 (1.1–2.1) |
[Arsenic measurements from 1950–94.] | SMRfemale | 34 | 2.7 (1.9–3.8) | ||||
Hinwood et al. 1999 [88] (Table Two) | 22 areas in Victoria, Australia | Incidence 1982-91 | Median water arsenic concentration ranging 13 μg˙•L-1 to 1,077 μg˙•L-1. [Selected areas were those where samples with soil and/or water arsenic concentration were generally in excess of 10 μg˙•L-1. Period for samples collection is not available.] | ICD 189.0, 189.9 | SIR | 134 | 1.16 (0.98–1.37) |
* Tsai et al. 1999 [41] (Tables Two, Three) | 4 townships from BFD endemic area in SW coast, Taiwan | Mortality 1971-94 | Median arsenic content of artesian well: 780 μg˙•L-1 (range: 350–1,140). | ICD 189 | SMRlocal-male | 94 | 6.76 (5.46–8.27) |
SMRnational-male | 94 | 6.80 (5.49–8.32) | |||||
Period of samples collection not reported. Authors state that artesian wells were no longer used by the mid-1970s. | SMRlocal-female | 128 | 8.89 (7.42–10.6) | ||||
[Comparison of mortality in BFD endemic area with that of a local reference population (Chiayi-Tainan county) and that of Taiwan as a whole.] | SMRnational-female | 128 | 10.5 (8.75–12.5) | ||||
*†Meliker et al. 2007 [90] (Table Two) | 6 counties, Southeastern Michigan, USA | Mortality 1979-97 | Population weighted median arsenic concentration in water of 7.58 μg˙•L-1, with a range between 10–100 μg˙•L-1. Data from 9,251 well water samples collected between 1983–2002. | ICD9 189 | SMRmale | 325 | 1.06 (0.91–1.22) |
SMRfemale | 194 | 1.00 (0.82–1.20) | |||||
†Yuan et al. 2010 [61] (Tables Two, Three) | Region II and V, Chile | Mortality 1950-2000 | Northern Chile (Region II) with population weighted average arsenic concentration in drinking water up to 569 μg˙•L-1 vs Region V with exposure close to 1 μg˙•L-1. Between 1958-70, arsenic concentration in water supply of Antofagasta and nearby Mejillones (Region II) averaged 870 μg˙•L-1 and declined in 1970s when treatment plants were installed. | ICD9 189; ICD10 C64-C66, C68 | Men and women aged 30+ years | ||
RRmale-1950–54 | 4 | 0.69 (0.23–2.02) | |||||
RRmale-1955–59 | 9 | 1.43 (0.66–3.10) | |||||
RRmale-1960–64 | 7 | 0.91 (0.40–2.08) | |||||
RRmale-1965–69 | 12 | 2.51 (1.22–5.17) | |||||
RRmale1970–74 | 15 | 1.45 (0.81–2.60) | |||||
RRmale1975–80 | 19 | 2.13 (1.24–3.68) | |||||
RRmale1981–85 | 39 | 3.37 (2.21–5.11) | |||||
RRmale1986–90 | 63 | 2.81 (2.05–3.85) | |||||
RRmale1991–95 | 50 | 1.78 (1.28–2.47) | |||||
RRmale1996–00 | 66 | 1.61 (1.21–2.14) | |||||
RRfemale-1950–54 | 2 | 1.27 (0.27–6.00) | |||||
RRfemale-1955–59 | 2 | 0.30 (0.07–1.25) | |||||
RRfemale-1960–64 | 7 | 1.66 (0.71–3.91) | |||||
RRfemale-1965–69 | 3 | 0.76 (0.23–2.57) | |||||
RRfemale1970–74 | 13 | 3.70 (1.81–7.56) | |||||
RRfemale1975–80 | 9 | 1.71 (0.80–3.65) | |||||
RRfemale1981–85 | 25 | 2.89 (1.77–4.72) | |||||
RRfemale1986–90 | 41 | 3.23 (2.18–4.78) | |||||
RRfemale1991–95 | 49 | 4.37 (2.98–6.41) | |||||
RRfemale1996–00 | 47 | 2.32 (1.64–3.28) | |||||
Young adults aged 30-39 years, born during and just before high-exposure period; and for ages 40+, born before 1950 with no early life exposure. | |||||||
SMRmale_30-49 years | 4 | 5.63 (1.52–14.4) | |||||
SMRmale_40 years+ | 103 | 2.68 (2.19–3.26) | |||||
SMRfemale_30-49 years | 4 | 9.52 (2.56–24.4) | |||||
SMRfemale_40 years+ | 84 | 3.91 (3.12–4.84) | |||||
SMRtotal_30-49 years | 8 | 7.08 (3.05–14.0) | |||||
SMRtotal_40 years+ | 187 | 3.12 (2.69–3.61) |