Public health and chronic low chlordecone exposure in Guadeloupe, Part 1: hazards, exposure-response functions, and exposures

Table 4 BMD₁₀ for liver carcinomas in male mice (data from NCI, 1976)

Model	Total number of parameters in the model	AIC	Goodness of fit test P-value	Scaled residual near BMR	BMD₁₀ (mg/kg/d)	BMD_10-HED (mg/kg/d)
Gamma-Restricted	3	157.911	NA	0	0.841	0.1279
Gamma	3	157.911	NA	0	0.841	0.1279
Logistic	2	155.911	0.9773	0.002	0.545	0.0828
LogLogistic-Restricted	3	157.911	NA	0	1.136	0.1725
LogLogistic	3	157.911	NA	0	1.136	0.1725
LogProbit-Restricted	3	157.911	NA	0	1.078	0.1638
LogProbit	3	157.911	NA	0	1.078	0.1638
Multistage-Restricted	2	157.911	NA	0	0.536	0.0814
Multistage	2	157.911	NA	0	0.536	0.0814
Multistage-Cancer 1	2	156.027	0.733	0.007	0.257	0.0391
Multistage-Cancer 2	3	157.911	NA	0	0.536	0.0814
Multistage-Cancer 3	4	159.911	NA	0	0.373	0.0567
Probit	2	155.914	0.9557	−0.005	0.535	0.0812
Weibull-Restricted	3	157.911	NA	0	0.674	0.1024
Weibull	3	157.911	NA	0	0.674	0.1024
Quantal-Linear	3	156.027	0.733	0.007	0.257	0.0391
Minimal BMD						0.0391
Maximal BMD						0.0828
Ratio max/min						2.1
BMD from best AIC model						0.083
Geometric mean of acceptable models BMD						0.057

The benchmark response is 10 %. AIC: Akaïke’s Information Criterion. BMD₁₀: Benchmark dose for 10 % excess risk. Results in bold are acceptable models according to these criteria: total number of parameters does not exceed the number of groups modeled (n = 3); and p-value > 0.1; and scaled residual < │2│ and no computation error or unrealistic graphical BMD₁₀. If ratio max/min is less than 3, then geometric mean of acceptable models is selected, else best AIC model is selected. “NA”: not applicable

ISSN: 1476-069X