References | Methods | Results |
---|---|---|
Animal Data | ||
RodrÃguez et al., 2010 [46] | Neonatal exposure of mice from D1 to D7 to BPA 0.05 or 20 mg/kg/day | ⇘ percentage of primordial follicles ⇗ percentages of growing follicles at 20 mg/kg/day dose by increased recruitment, ⇗ proliferation of granulosa cells at every follicular stage |
Zhang et al., 2012 [45] | Exposure of pregnant mice at 0.02, 0.04 or 0.08 mg/kg/day of orally administered BPA from Day 12.5 post coïtum. | ⇘ number of primordial follicles at D3 by defaults in assembly associated with. a delay in meiosis I progression ⇘ mRNA expression of specific meiotic genes |
Li et al., 2014 [47] | Intraperitoneal injection of 10, 40 or 160 mg/kg of BPA in prepubertal rats for 1 week | ⇘ ovary weight, ⇘ number of primordial follicles at the highest dose, dose –dependant ⇘ in numbers of total, primary/preantral and antral follicles, ⇗ number of atretic follicles |
Berger et al., 2015 [44] | Exposure of pregnant mice to BPA: 0.5, 20 or 50 μg/kg/day, histological analysis of ovaries and gene expression analysis at postnatal D4 and D21 from F1 to F3 | Alteration in the number of follicles for F1, but not for F2 and F3. Alterations in ovarian gene expression at D21 with a transgenerational effect |