A systematic comparison of statistical methods to detect interactions in exposome-health associations

Table 2 Characteristics and performance measures available for each method

Feature	EWAS₂	DSA₁	DSA₂	Sun3step	LASSO	GLINTERNET	BRT
	Model structure
Provides regression coefficients		✓	✓	✓	✓	✓
Able to include interaction terms	✓		✓	✓		✓	✓
Able to include confounder covariates	✓	✓	✓	✓	✓
Able to capture non-linear associations			✓	✓			✓
	Measures of performance
RMS	✓	✓	✓	✓	✓	✓
RNV	✓	✓	✓	✓	✓	✓	✓
\(R^{2}_{\text {rel}}\)		✓	✓	✓	✓	✓	✓
Sens	✓	✓	✓	✓	✓	✓
AltSens	✓	✓	✓	✓	✓	✓	✓
Sensvar	✓	✓	✓	✓	✓	✓	✓
Sens₂	✓		✓	✓		✓
AltSens₂	✓		✓	✓		✓
FDP	✓	✓	✓	✓	✓	✓
AltFDP	✓	✓	✓	✓	✓	✓	✓
FDPvar	✓	✓	✓	✓	✓	✓	✓
FDP₂	✓		✓	✓		✓
AltFDP₂	✓		✓	✓		✓

ISSN: 1476-069X