Table 3 Association between SNPs and NIHL risk
SNP | Genetic model | Genotype | Controls, n (%) | Cases, n (%) | P | OR(95%CI)a |
|---|---|---|---|---|---|---|
rs1049216 | Additive | CC | 173(64.3) | 195(72.5) | 1.0 | |
CT | 82(30.5) | 68(25.3) | 0.050 | 0.609(0.372–1.000) | ||
TT | 14(5.2) | 6(2.2) | 0.032 | 0.246(0.069–0.886) | ||
Dominant | CC | 173(64.3) | 195(72.5) | 1.0 | ||
CT + TT | 96(35.7) | 72(27.5) | 0.014 | 0.551(0.343–0.885) | ||
Recessive | CC + CT | 258(94.8) | 266(97.8) | 1.0 | ||
TT | 14(5.2) | 6(2.2) | 0.047 | 0.277(0.078–0.986) | ||
rs6948 | Additive | AA | 177(65.8) | 198(73.6) | 1.0 | |
AC | 79(29.4) | 65(24.2) | 0.050 | 0.607(0.369–1.000) | ||
CC | 13(4.8) | 6(2.2) | 0.089 | 0.328(0.091–1.185) | ||
Dominant | AA | 177(65.8) | 198(73.6) | 1.0 | ||
AC + CC | 92(34.2) | 71(26.4) | 0.020 | 0.568(0.352–0.916) | ||
Recessive | AA + AC | 256(95.2) | 263(97.8) | 1.0 | ||
CC | 13(4.8) | 6(2.2) | 0.128 | 0.373(0.105–1.327) | ||
Risk genotypeb | 0 | 91(33.8) | 71(26.4) | 1.0 | ||
1 | 6(2.2) | 3(1.1) | 0.701 | 0.684(0.098–4.779) | ||
2 | 172(63.9) | 195(72.5) | 0.018 | 1.787(1.104–2.892) | ||