From: The effect of high polycyclic aromatic hydrocarbon exposure on biological aging indicators
Interval variables Frequency variables | Median(min; max) Number(%) | Statistical tests and p-values@ | |
---|---|---|---|
Coke-oven workers n=49 | Controls n=45 | ||
General characteristics and PAHs§exposure | |||
Age (Years) | 36(20−59) | 37(21−58) | 0.911 |
Dieta | 8(16%) | 8(18%) | 0.852 |
Fruit and vegetablesb | 27(55%) | 22(49%) | 0.549 |
Indoor PAH exposurec | 26(53%) | 18(40%) | 0.205 |
Outdoor PAH exposured | 17(34%) | 16(36%) | 0.930 |
Nicotine & metabolites (mg/mmol creatinine)e | 0(0%) | 0(0%) | |
Former smokers | 20(41%) | 16(36%) | 0.600 |
Years since cessation | 6(1-26) | 7(1-20) | 0.640 |
Length of work in the cokery (years) | 10.5 (1; 40.0) | 0 (0; 0) | |
1-pyrenol (μmoles/mol creatinine) f | 3.1(0.4; 7.5) | 0.1(0.0; 0.4) | 0.00001 |
Occup_PAHsg | 36.2(3.6; 253.0) | 0(0; 0) | 0.00001 |
Environ_PAHsh | 0.01313(-0.0471; 0.0607) | -0.0131(-0.0970; 0.0378) | 0.0001 |
nDNA_changesi | 1.7377(-0.0006; 4.0372) | -0.5360 (-1.0397; 0.9357) | 0.00001 |
Genotoxic alterations | |||
Anti-BPDE-DNA adducts (adducts/108 nucleotides) k | 5.1 (0.9; 12.2) | 0.1 (0.1; 5.6) | 0.00001 |
MN (MN/1000BN cells) | 4 (1.0; 11.0) | 0.01 (0; 4.0) | 0.00001 |
Epigenetic alterations | |||
LINE-1 (%mC) | 80.3(56.91; 83.7) | 75.7(55.7; 85.7) | 0.00001 |
p53 (%mC) | 11.8(5.6; 25.1) | 18.6(6.9; 46.2) | 0.0003 |
Alu (%mC) | 23.6(21.8; 24.5) | 22.9(20.6; 24.4) | 0.0007 |
HICI (%mC) | 17.2(10.4; 33.0) | 20.4(7.4; 34.4) | 0.048 |
IL-6 (%mC) | 48.4(34.5; 69.9) | 44.7(28.7; 61.8) | 0.095 |
p16 (%mC) | 1.9(1.3; 3.6) | 2.1(0.8; 3.9) | 0.205 |
GSTM1 genotyping | |||
*0/*0 | 18(41%) | 25(54%) | 0.204 |
*1/*1 and *0/*1 | 26(59%) | 22(46%) | |
Outcomes | |||
DNAmAge l | 37(17.0; 54.0) | 36(19.0; 52.0) | 0.567 |
AgeAcc m | -1(-22.0; 15.0) | -3(-13.0; 4.0) | 0.096 |
Subjects with AgeAcc ≥ 0 N (%) | 20(40.8%) | 7(15.6%) | 0.007 |
TL n | 1.0(0.3; 3.0) | 1.2(0.4; 2.1) | 0.038 |
mtDNAcno | 1.0(0.4; 2.5) | 0.9(0.3; 1.7) | 0.128 |