Genetic susceptibility to airway inflammation and exposure to short-term outdoor air pollution

Table 4 Gene-environment interactions between pollutant exposure and genotypes on FeNO50 estimated from single and multipollutant quantile regression models (50^th percentile)

SNP	Pollutant (exposure window)	Single pollutant				Multi pollutant
SNP	Pollutant (exposure window)	p-value^a	Marginal effect coefficient (95%CI)			p-value^a	Marginal effect coefficient (95%CI)
rs7830^b (NOS3) (n = 3599)	NO₂ (24 h)	0.047	GG 0.259 (-0.150, 0.668)	TG/TT -0.264 (-0.628, 0.100)		0.033	GG 0.409 (-0.277, 1.094)	TG/TT -0.149 (-0.825, 0.526)
rs4795051^c (NOS2) (n = 3612)	NO_x (3 h)	0.155 (GC)	CC -0.060 (-0.137, 0.016)	GC 0.012 (-0.053, 0.076)	GG -0.033 (-0.145, 0.080)	0.048 (GC)	CC -0.027 (-0.153, 0.098)	GC 0.073 (-0.043, 0.189)	GG 0.034 (-0.111, 0.179)

All 3-h interaction analyses are adjusted for age, height, year, month, current cold, and atopy. All 24- and 120-h interaction analyses are adjusted for age, height, year, month, current cold, atopy, and temperature. All estimates are given per 10 µg/m³ increase in air pollutant exposure
^ap-value for interaction term. For additive models the genotype with significant difference from the major allele genotype is presented in parentheses
^bDominant model
^cAdditive model

ISSN: 1476-069X