Table 5 Gene-environment interactions between pollutant exposure and genotypes on FeNO270 estimated from single and multipollutant quantile regression models (50th percentile)
From: Genetic susceptibility to airway inflammation and exposure to short-term outdoor air pollution
SNP | Pollutant (exposure window) | Single pollutant | Multi pollutant | ||||||
|---|---|---|---|---|---|---|---|---|---|
p-valuea | Marginal effect coefficient (95%CI) | p-valuea | Marginal effect coefficient (95%CI) | ||||||
rs2266637 (GSTT1) (n = 2880) | NO2 (120 h) | 0.038 | CC -0.113 (-0.255, 0.030) | GG 0.170 (-0.063, 0.403) | 0.019 | CC -0.035 (-0.314, 0.244) | GG 0.298 (-0.080, 0.677) | ||
rs4795051b (NOS2) (n = 3398) | PM10 (3 h) | 0.003 (GC) | CC -0.092 (-0.179, -0.006) | GC 0.073 (0.000, 0.147) | GG 0.007 (-0.107, 0.120) | 0.004 (GC) | CC -0.079 (-0.169, 0.011) | GC 0.081 (0.004, 0.159) | GG 0.028 (-0.088, 0.143) |
PM10 (24Â h) | 0.050 (GC) | CC -0.111 (-0.262, 0.040) | GC 0.075 (-0.044, 0.195) | GG 0.018 (-0.190, 0.195) | 0.066 (GC) | CC -0.129 (-0.287, 0.029) | GC 0.045 (-0.085, 0.175) | GG -0.004 (-0.218, 0.210) | |
NO2 (24Â h) | 0.039 (GG) | CC -0.051 (-0.173, 0.072) | GC -0.009 (-0.106, 0.088) | GG 0.163 (-0.007, 0.333) | 0.036 (GG) | CC -0.059 (-0.241, 0.124) | GC -0.011 (-0.184, 0.162) | GG 0.157 (-0.075, 0.389) | |
NO2 (120Â h) | 0.004 (GG) | CC -0.188 (-0.359, -0.018) | GC -0.007 (-0.150, 0.136) | GG 0.234 (-0.008, 0.475) | 0.007 (GG) | CC -0.213 (-0.507, 0.082) | GC -0.049 (-0.308, 0.209) | GG 0.189 (-0.146, 0.524) | |
NOx (120Â h) | 0.017 (GG) | CC -0.057 (-0.115, 0.002) | GC 0.005 (-0.055, 0.064) | GG 0.065 (-0.022, 0.152) | 0.035 (GG) | CC -0.014 (-0.106, 0.078) | GC 0.051 (-0.054, 0.155) | GG 0.094 (-0.022, 0.209) | |
rs2248814b (NOS2) (n = 3398) | PM10 (3 h) | 0.033 (GA) 0.046 (AA) | GG -0.070 (-0.157, 0.017) | GA 0.055 (-0.023, 0.132) | AA 0.078 (-0.041, 0.197) | 0.042 (GA) 0.079 (AA) | GG -0.063 (-0.153, 0.027) | GA 0.052 (-0.028, 0.133) | AA 0.064 (-0.056, 0.184) |