Fig. 6
Bivariate associations between prenatal OPE urinary metabolite mixtures (ng/mL) and CBCL composite raw scores, using BKMR (N = 204). Figure 6 shows the bivariate association between each OPE metabolite (labelled in the column) and CBCL composite score (Y axis), while setting a second metabolite (labelled in the row) to its 25th, 50th, and 75th percentile and all other metabolites to their median. All models were adjusted for recruitment site, maternal age, race/ethnicity, household annual income, education, pre-pregnancy BMI, GA at sample collection, child adjusted age at CBCL administration, season, infant birth order, child sex. OPE metabolites and CBCL raw scores were natural log-transformed, mean centered, and standard deviation scaled. Continuous covariates were mean-centered and standard deviation scaled. Note: BKMR, Bayesian Kernel Machine Regression; OPE, Organophosphate Ester; CBCL, Child Behavior Checklist; DPHP, Diphenyl phosphate; DNBP + DIBP, Sum of Di-n-butyl phosphate and Di-isobutyl phosphate; BDCIPP, Bis(1,3-dichloro-2-propyl) phosphate; BCEP, Bis(2-chloroethyl) phosphate; BBOEP, Bis(butoxethyl) phosphate. Possible interactions were visually identified between the following metabolites for: internalizing scores (BDCIPP and BBOEP, DNBP + DIBP and BBOEP, DPHP and BBOEP, DNBP + DIBP and BCEP, DPHP and BCEP, BCEP and DNBP + DIBP, and DNBP + DIBP and BDCIPP), externalizing scores (BCEP and BBOEP, BDCIPP and BBOEP, DNBP + DIBP and BBOEP, and DPHP and BBOEP), and total problems scores (BCEP and BBOEP, BDCIPP and BBOEP, DNBP + DIBP and BBOEP, DPHP and BBOEP, DNBP + DIBP and BCEP, DPHP and BCEP, BCEP and DNBP + DIBP, BCEP and DPHP, and DNBP + DIBP and DPHP)