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Table 3 Individual associations between third trimester urinary OPE metabolites (ng/mL) and CBCL raw composite scores (N = 204)

From: Prenatal exposures to organophosphate ester metabolite mixtures and children’s neurobehavioral outcomes in the MADRES pregnancy cohort

 

Internalizing

Externalizing

Total Problems

Unadjusted

β (95% CI)

Adjusteda

β (95% CI)

Unadjusted

β (95% CI)

Adjusteda

β (95% CI)

Unadjusted

β (95% CI)

Adjusteda

β (95% CI)

DPHP

 T1 (< 0.55)

REF

REF

REF

REF

REF

REF

 T2 (0.55–1.15)

0.82 (0.52, 1.31)

0.89 (0.56, 1.41)

0.86 (0.59, 1.26)

0.87 (0.59, 1.26)

0.85 (0.61, 1.17)

0.87 (0.63, 1.20)

 T3 (≥ 1.15)

1.04 (0.65, 1.65)

1.03 (0.64, 1.64)

1.10 (0.75, 1.60)

1.01 (0.68, 1.48)

1.10 (0.79, 1.52)

1.04 (0.75, 1.44)

DNBP + DIBP

 T1 (< 0.14)

REF

REF

REF

REF

REF

REF

 T2 (0.14–0.21)

1.01 (0.64, 1.61)

1.06 (0.66, 1.69)

1.09 (0.74, 1.60)

1.04 (0.71, 1.52)

1.00 (0.72, 1.38)

0.97 (0.70, 1.35)

 T3 (≥ 0.21)

1.06 (0.66, 1.68)

1.18 (0.74, 1.88)

1.13 (0.77, 1.66)

1.15 (0.78, 1.68)

1.04 (0.75, 1.45)

1.09 (0.78, 1.50)

BDCIPP

 T1 (< 0.85)

REF

REF

REF

REF

REF

REF

 T2 (0.85–1.83)

0.99 (0.62, 1.57)

1.01 (0.62, 1.64)

1.04 (0.71, 1.52)

0.99 (0.66, 1.47)

1.05 (0.75, 1.45)

1.02 (0.72, 1.43)

 T3 (≥ 1.83)

0.86 (0.54, 1.37)

0.97 (0.59, 1.61)

1.15 (0.78, 1.68)

1.16 (0.77, 1.75)

1.07 (0.77, 1.48)

1.12 (0.79, 1.59)

BCEP

 T1 (Non-detect)

REF

REF

REF

REF

REF

REF

 T2 (0.04–0.97)

1.10 (0.69, 1.75)

1.19 (0.75, 1.90)

1.06 (0.72, 1.55)

1.14 (0.78, 1.68)

1.00 (0.72, 1.39)

1.04 (0.75, 1.44)

 T3 (≥ 0.97)

1.06 (0.66, 1.69)

1.20 (0.74, 1.93)

1.03 (0.70, 1.51)

1.12 (0.75, 1.66)

1.04 (0.75, 1.44)

1.09 (0.78, 1.53)

BBOEP

 T1 (Non-detect)

REF

REF

REF

REF

REF

REF

 T2 (0.01–0.06)

1.32 (0.83, 2.08)

1.25 (0.79, 1.98)

1.52 (1.05–2.21)

1.43 (0.99, 2.09)

1.34 (0.97, 1.84)

1.26 (0.92, 1.74)

 T3 (≥ 0.06)

0.88 (0.56, 1.38)

0.78 (0.48, 1.25)

0.97 (0.67, 1.41)

0.87 (0.59, 1.29)

0.93 (0.67, 1.27)

0.84 (0.60, 1.17)

BCIPP

 T1 (Non-detect)

REF

REF

REF

REF

REF

REF

 T2 (0.03- 0.66)

0.78 (0.49, 1.23)

0.72 (0.46, 1.15)

0.90 (0.62, 1.32)

0.89 (0.61, 1.31)

0.87 (0.63, 1.20)

0.85 (0.62, 1.18)

 T3 (≥ 0.66)

1.32 (0.84, 2.09)

1.47 (0.93, 2.34)

1.36 (0.93, 1.98)

1.33 (0.99, 1.95)

1.22 (0.88, 1.68)

1.21 (0.87, 1.67)

BMPP

 Non-detect

REF

REF

REF

REF

REF

REF

 Detect

1.42 (0.97, 2.08)

1.45 (0.98, 2.14)

1.39 (1.01, 1.90)

1.42 (1.04, 1.96)

1.34 (1.02, 1.75)

1.35 (1.03, 1.78)

BEHP

 Non-detect

REF

REF

REF

REF

REF

REF

 Detect

1.21 (0.78, 1.87)

1.13 (0.73, 1.76)

1.08 (0.75, 1.55)

1.01 (0.77, 1.45)

1.15 (0.85, 1.56)

1.10 (0.81, 1.50)

DPRP

 Non-detect

REF

REF

REF

REF

REF

REF

 Detect

0.84 (0.55, 1.29)

0.85 (0.56, 1.31)

1.08 (0.75, 1.53)

1.10 (0.77, 1.56)

0.96 (0.71, 1.30)

0.97 (0.72, 1.31)

  1. All \(\beta {\prime}s\) have been exponentiated for interpretation
  2. OPE Organophosphate Ester, T1 Tertile 1, T2 Tertile 2, T3 Tertile 3, CBCL Child Behavior Checklist, DPHP Diphenyl phosphate, DNBP + DIBP Sum of Di-n-butyl phosphate and Di-isobutyl phosphate, BDCIPP Bis(1,3-dichloro-2-propyl) phosphate, BCEP Bis(2- chloroethyl) phosphate, BBOEP Bis(butoxethyl) phosphate, BCIPP Bis(1-chloro-2-propyl) phosphate, BMPP Bis(2-methylphenyl) phosphate, BEHP Bis(2-ethylhexyl) phosphate, DPRP Dipropyl phosphate, GA Gestational age, BMI Body Mass Index
  3. aModel adjusted for recruitment site, maternal age, race/ethnicity, household annual income, education, pre-pregnancy BMI, GA at sample collection, child adjusted age at CBCL administration, season, infant birth order, child sex
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