Prenatal exposures to organophosphate ester metabolite mixtures and children’s neurobehavioral outcomes in the MADRES pregnancy cohort

Table 4 Posterior inclusion probabilities (PIPs) and single exposure effect estimates for each prenatal OPE metabolite in the Bayesian kernel machine regression (BKMR) mixture and CBCL composite raw score

Metabolite	PIPs	Effect Estimates	95% Credible Interval
Internalizing Scale
DPHP	0.27	0.002	-0.17, 0.18
DNBP + DIBP	0.53	0.15	-0.02, 0.32
BDCIPP	0.34	-0.09	-0.24, 0.06
BCEP	0.37	0.15	-0.10, 0.41
BBOEP	0.64^a	-0.10	-0.33, 0.14
Externalizing Scale
DPHP	0.15	0.04	-0.13, 0.20
DNBP + DIBP	0.19	0.02	-0.13, 0.17
BDCIPP	0.15	-0.04	-0.17, 0.10
BCEP	0.20	0.11	-0.14, 0.36
BBOEP	0.81^a	-0.02	-0.28, 0.24
Total Problems Scale
DPHP	0.24	0.03	-0.14, 0.21
DNBP + DIBP	0.30	0.06	-0.10, 0.22
BDCIPP	0.26	-0.04	-0.19, 0.10
BCEP	0.28	0.11	-0.15, 0.36
BBOEP	0.59^a	-0.07	-0.31, 0.17

Effect estimates reflect the difference in CBCL composite score for a change in the specified metabolite from the 25th to 75th percentile, holding all other metabolites in the mixture at their median values and adjusting for recruitment site, maternal age, race/ethnicity, household annual income, education, pre-pregnancy BMI, GA at sample collection, child adjusted age at CBCL administration, season, infant birth order, child sex
OPE Organophosphate Ester, CBCL Child Behavior Checklist, DPHP Diphenyl phosphate, DNBP + DIBP Sum of Di-n-butyl phosphate and Di-isobutyl phosphate, BDCIPP Bis(1,3-dichloro-2-propyl) phosphate, BCEP Bis(2-chloroethyl) phosphate, BBOEP Bis(butoxethyl) phosphate
^aHighest PIPs value

ISSN: 1476-069X