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Table 2 Multivariate models* predicting AU/ASD and DD the CHARGE Study, 2003-2005.

From: Polybrominated diphenyl ethers in relation to autism and developmental delay: a case-control study

 

Plasma Concentration**

          
 

ln (ng/g lipid)

ln (pmol/g lipid)

AU/ASD vs. TD

DD vs. TD

Predictor variable

(25th, 75th)

(25th, 75th)

β

SE

OR†

90% CI

p-value

β

SE

OR†

90% CI

p-value

   BDE 28

(-0.47, 0.70)

(0.43, 1.60)

-0.17

0.38

0.82

(0.39, 1.71)

0.66

0.34

0.49

1.48

(0.58, 3.82)

0.49

   BDE 47

(3.56, 4.75)

(4.28, 5.47)

-0.24

0.32

0.75

(0.40, 1.42)

0.46

0.35

0.44

1.52

(0.65, 3.58)

0.42

   BDE 66

(-1.41, -0.11)

(-0.69, 0.61)

-0.39

0.38

0.60

(0.27, 1.36)

0.30

0.48

0.42

1.86

(0.76, 4.59)

0.26

   BDE 85

(0.53, 1.91)

(1.10, 2.48)

-0.50

0.31

0.50

(0.25, 1.02)

0.11

0.32

0.39

1.55

(0.64, 3.77)

0.42

   BDE 99

(2.57, 3.90)

(3.14, 4.47)

-0.33

0.32

0.65

(0.32, 1.31)

0.31

0.46

0.38

1.84

(0.80, 4.25)

0.23

   BDE 100

(2.61, 3.68)

(3.18, 4.25)

-0.32

0.31

0.71

(0.41, 1.23)

0.31

0.41

0.43

1.55

(0.72, 3.34)

0.34

   BDE 153

(2.47, 3.61)

(2.91, 4.05)

-0.63

0.41

0.49

(0.23, 1.05)

0.12

0.61

0.48

1.99

(0.81, 4.91)

0.21

   BDE 183

(-0.77, -0.18)

(-0.44, 0.15)

-0.25

0.56

0.87

(0.50, 1.49)

0.66

0.05

0.53

1.03

(0.62, 1.72)

0.92

   Σ BDE 28 - 153

-

(5.08, 6.10)

-0.34

0.37

0.71

(0.38, 1.32)

0.36

0.51

0.46

1.69

(0.78, 3.65)

0.26

   Σ BDE 28 - 183

-

(5.11, 6.10)

-0.34

0.38

0.71

(0.38, 1.33)

0.37

0.52

0.46

1.67

(0.78, 3.58)

0.26

   BDE 197

(-0.35, 0.81)

(-0.13, 1.04)

-0.44

0.39

0.60

(0.28, 1.26)

0.25

-0.63

0.39

0.48

(0.23, 1.00)

0.10

   BDE 207

(0.50, 1.00)

(0.63, 1.13)

-0.42

0.55

0.81

(0.51, 1.28)

0.45

-0.86

0.60

0.65

(0.40, 1.07)

0.15

   BDE 209

(0.53, 1.58)

(0.57, 1.62)

-0.42

0.42

0.65

(0.31, 1.34)

0.32

-0.49

0.46

0.60

(0.27, 1.32)

0.29

   Σ BDE 197 - 209

-

(1.61, 2.44)

-0.51

0.52

0.65

(0.32, 1.34)

0.33

-0.76

0.56

0.53

(0.25, 1.15)

0.18

   Σ BDE 28 - 209

-

(5.15, 6.12)

-0.35

0.39

0.71

(0.38, 1.33)

0.37

0.51

0.47

1.64

(0.77, 3.50)

0.28

Mother's education‡

            

≤ high school

-

-

-0.60

0.85

0.55

(0.13, 2.23)

0.48

1.50

0.87

4.49

(1.07, 18.90)

0.09

some college

-

-

1.10

0.73

3.01

(0.90, 10.01)

0.13

1.75

0.86

5.75

(1.40, 23.59)

0.04

Calendar time‡

-

-

-1.11

0.55

0.33

(0.13, 0.81)

0.04

-0.67

0.68

0.51

(0.17, 1.56)

0.32

  1. *Each congener or subset of congeners was entered, log-transformed and lipid-adjusted, into a separate multinomial logistic regression model to predict AU/ASD or DD.
  2. ** Percentiles are presented as log-transformed values of concentrations in lipids
  3. † Odds ratio for difference in PBDE levels comparing those at 75th and 25th percentiles
  4. ‡All models were fitted with multivariate adjustment for mother's education (reference group is college degree) and calendar time, and the results for these factors were similar across models. What we present in the table was a model with mother's education and calendar time without PBDE.
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Environmental Health

ISSN: 1476-069X