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Table 2 Selected DEa-Related Rat Studies on Lung Tumorgenicity.

From: Risk assessment of diesel exhaust and lung cancer: combining human and animal studies after adjustment for biases in epidemiological studies

Study Exposure Duration DE concentration during exposure (mg/m3) 30-month average continuous concentration (μg/m3) No. of animals examined No. of animals with lung tumors % of animals with lung tumors
Nikula et al. [31] 80 hours/week, 0 0 214 3 1.4
  24 months 2.44 930 210 17 8.1
   6.33 2400 212 55 25.9
Brightwell et al. [29] 80 hours/week 0 0 250 4 1.6
  24 months 0.70 270 112 1 8.9
   2.20 840 112 14 12.5
   6.60 2500 111 55 49.6
Mauderly et al. [32] 35 hours/week 0 0 230 2 0
  30 months 0.35 73 223 3 0.35
   3.5 730 222 8 3.5
   7.08 1,480 227 29 7.08
  1. a DE: diesel exhaust