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Table 5 SGA adjusted odds ratio for gestational exposure to internal dose THMs

From: Individual exposures to drinking water trihalomethanes, low birth weight and small for gestational age risk: a prospective Kaunas cohort study

THM exposure Tertile limits (mg/d)

SGA cases

Non SGA

Entire pregnancy ORa95% CI

First trimester ORa95% CI

Second trimester ORa95% CI

Third trimester ORa95% CI

TTHMb

      

0.0025-0.0386

76

1010

Reference

Reference

Reference

Reference

0.0386-0.3545

92

1058

1.18 (0.86-1.82)

1.13 (0.82-1.54)

1.18 (0.86-1.62)

1.17 (0.85-1.60)

0.3545-2.4040

102

1003

1.34 (0.98-1.84)

1.27 (0.93-1.73)

1.33 (0.97-1.82)

1.22 (0.89-1.67)

Continuous 0.1 μg/L

  

1.03 (0.99-1.07)

1.02 (0.98-1.06)

1.03 (0.99-1.07)

1.02 (0.98-1.06)

Chloroform

      

0.0013-0.0249

78

1012

Reference

Reference

Reference

Reference

0.0249-0.2868

91

1054

1.16 (0.84-1.59)

1.19 (0.86-1.63)

1.12 (0.82-1.54)

1.19 (0.87-1.63)

0.2868-2.1328

101

1005

1.31 (0.96-1.79)

1.30 (0.95-1.77)

1.28 (0.94-1.74)

1.22 (0.89-1.68)

Continuous 0.1 μg/L

  

1.03 (0.99-1.08)

1.03 (0.99-1.08)

1.03 (0.99-1.08)

1.04 (1.00-1.09)

CHBrCl2

      

0.0001-0.0124

73

1018

Reference

Reference

Reference

Reference

0.0124-0.0501

101

1045

1.35 (0.99-1.86)

1.21 (0.88-1.67)

1.20 (0.88-1.65)

1.37 (1.00-1.88)

0.0501-0.3359

96

1008

1.29 (0.94-1.78)

1.35 (0.99-1.85)

1.23 (0.90-1.69)

1.25 (0.91-1.73)

Continuous 0.01 μg/L

  

1.21 (0.90-1.62)

1.19 (0.87-1.62)

1.19 (0.89-1.60)

1.20 (0.90-1.62)

CHBr2Cl

      

0.0000-0.0000

102

1013

Reference

Reference

Reference

Reference

0.0000-0.0039

78

1045

0.77 (0.56-1.05)

0.76 (0.54-1.07)

0.66 (0.48-0.91)

1.76 (0.56-1.03)

0.0039-0.0644

90

1012

0.89 (0.66-1.21)

0.88 (0.67-1.17)

0.90 (0.68-1.21)

0.85 (0.63-1.15)

Continuous 0.01 μg/L

  

1.05 (0.89-1.24)

1.05 (0.86-1.26)

1.05 (0.86-1.26)

1.06 (0.92-1.22)

  1. aadjusted for: previous preterm delivery, maternal education, marital status, smoking, alcohol consumption, body mass index, maternal age, parity, and birth year.
  2. bTTHM, total trihalomethane; OR, odds ratio; CI, confidence intervals; CHBr2Cl, dibromochloromethane; CHBrCl2, bromodichloromethane.