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Table 5 SGA adjusted odds ratio for gestational exposure to internal dose THMs

From: Individual exposures to drinking water trihalomethanes, low birth weight and small for gestational age risk: a prospective Kaunas cohort study

THM exposure Tertile limits (mg/d) SGA cases Non SGA Entire pregnancy ORa95% CI First trimester ORa95% CI Second trimester ORa95% CI Third trimester ORa95% CI
TTHMb       
0.0025-0.0386 76 1010 Reference Reference Reference Reference
0.0386-0.3545 92 1058 1.18 (0.86-1.82) 1.13 (0.82-1.54) 1.18 (0.86-1.62) 1.17 (0.85-1.60)
0.3545-2.4040 102 1003 1.34 (0.98-1.84) 1.27 (0.93-1.73) 1.33 (0.97-1.82) 1.22 (0.89-1.67)
Continuous 0.1 μg/L    1.03 (0.99-1.07) 1.02 (0.98-1.06) 1.03 (0.99-1.07) 1.02 (0.98-1.06)
Chloroform       
0.0013-0.0249 78 1012 Reference Reference Reference Reference
0.0249-0.2868 91 1054 1.16 (0.84-1.59) 1.19 (0.86-1.63) 1.12 (0.82-1.54) 1.19 (0.87-1.63)
0.2868-2.1328 101 1005 1.31 (0.96-1.79) 1.30 (0.95-1.77) 1.28 (0.94-1.74) 1.22 (0.89-1.68)
Continuous 0.1 μg/L    1.03 (0.99-1.08) 1.03 (0.99-1.08) 1.03 (0.99-1.08) 1.04 (1.00-1.09)
CHBrCl2       
0.0001-0.0124 73 1018 Reference Reference Reference Reference
0.0124-0.0501 101 1045 1.35 (0.99-1.86) 1.21 (0.88-1.67) 1.20 (0.88-1.65) 1.37 (1.00-1.88)
0.0501-0.3359 96 1008 1.29 (0.94-1.78) 1.35 (0.99-1.85) 1.23 (0.90-1.69) 1.25 (0.91-1.73)
Continuous 0.01 μg/L    1.21 (0.90-1.62) 1.19 (0.87-1.62) 1.19 (0.89-1.60) 1.20 (0.90-1.62)
CHBr2Cl       
0.0000-0.0000 102 1013 Reference Reference Reference Reference
0.0000-0.0039 78 1045 0.77 (0.56-1.05) 0.76 (0.54-1.07) 0.66 (0.48-0.91) 1.76 (0.56-1.03)
0.0039-0.0644 90 1012 0.89 (0.66-1.21) 0.88 (0.67-1.17) 0.90 (0.68-1.21) 0.85 (0.63-1.15)
Continuous 0.01 μg/L    1.05 (0.89-1.24) 1.05 (0.86-1.26) 1.05 (0.86-1.26) 1.06 (0.92-1.22)
  1. aadjusted for: previous preterm delivery, maternal education, marital status, smoking, alcohol consumption, body mass index, maternal age, parity, and birth year.
  2. bTTHM, total trihalomethane; OR, odds ratio; CI, confidence intervals; CHBr2Cl, dibromochloromethane; CHBrCl2, bromodichloromethane.