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Table 4 Results for rs1062923-PM2.5 interactions 7 day moving averages†

From: Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules: the Normative Aging Study

Endothelial Marker

Number of participants

% change (95% CI)

Unadjusted p-value For interaction

Adjusted p-value

sICAM-1 homozygous carriers

31

-9.0 (-15.0, -2.5)

0.0002*

0.004*

Wild-type and heterozygotes

686

3.4 (1.9, 4. 9)

  

sVCAM-1 homozygous carriers

31

-9.2 (-17.2,-0.5)

0.005

0.1

Wild-type and heterozygotes

686

2.8 (0.9, 4.8)

  
  1. †IQR change in7 day moving average of PM2.5 = 4.27 μg/m3
  2. *models adjusted for education (≤12 years, 13-16 years, >16 years), ≥2 alcoholic drinks per day, age at first adhesion molecule measurement, time since first measurement, body mass index (BMI), diabetes diagnosi or fasting glucose >126 mg/dL, smoking status, pack-years smoked, hypertension medication use (yes/no), statin use, apparent temperature, seasonality (sine and cosine of month), CRP >10 mg/L.