Skip to main content

Table 5 Association between breast cancer and various cumulative PCE exposure

From: Risk of breast cancer following exposure to tetrachloroethylene-contaminated drinking water in Cape Cod, Massachusetts: reanalysis of a case-control study using a modified exposure assessment

Prior Analysis

 

PCE EXPOSURE LEVEL

Latency period (years)

≤Median

>Median

>75th Percentile

>90th Percentile

0

    

Case/control

91/109

100/108

59/54

18/21

COR (95% CI)

1.2 (0.9-1.6)

1.4 (1.0-1.8)

1.6 (1.1-2.3)

1.3 (0.7-2.4)

AOR (95% CI)

1.0 (0.7-1.3)

1.2 (0.9-1.7)

1.6 (1.1-2.4)

1.3 (0.7-2.6)

5

    

Case/control

79/82

75/81

50/40

17/16

COR (95% CI)

1.4 (1.0-2.0)

1.4 (1.0-1.9)

1.8 (1.2-2.8)

1.6 (0.8-3.1)

AOR (95% CI)

1.1 (0.8-1.5)

1.3 (0.9-1.8)

1.6 (1.0-2.6)

1.5 (0.7-3.0)

7

    

Case/control

59/68

69/67

46/33

17/13

COR (95% CI)

1.3 (0.9-1.8)

1.5 (1.1-2.1)

2.0 (1.3-3.2)

1.9 (0.9-4.0)

AOR (95% CI)

0.9 (0.6-1.3)

1.3 (0.9-1.9)

1.8 (1.1-2.9)

1.7 (0.8-3.6)

9

    

Case/control

48/55

63/55

40/27

16/11

COR (95% CI)

1.3 (0.9-1.9)

1.7 (1.2-2.4)

2.2 (1.3-3.6)

2.1 (1.0-4.6)

AOR (95% CI)

0.9 (0.6-1.4)

1.4 (0.9-2.0)

1.9 (1.1-3.2)

1.9 (0.8-4.4)

11

    

Case/control

39/42

47/41

29/20

12/8

COR (95% CI)

1.4 (0.9-2.1)

1.7 (1.1-2.6)

2.1 (1.2-3.8)

2.2 (0.9-5.4)

AOR (95% CI)

1.0 (0.6-1.5)

1.4 (0.9-2.1)

1.8 (1.0-3.3)

1.8 (0.7-4.8)

13

    

Case/control

35/26

30/26

17/13

8/5

COR (95% CI)

2.0 (1.2-3.3)

1.7 (1.0-2.9)

1.9 (0.9-4.0)

2.3 (0.8-7.2)

AOR (95% CI)

1.4 (0.8-2.3)

1.3 (0.8-2.3)

1.6 (0.7-3.5)

1.7 (0.5-5.2)

15

    

Case/control

26/18

18/17

12/8

2/3

COR (95% CI)

2.1 (1.2-3.9)

1.6 (0.8-3.0)

2.2 (0.9-5.4)

1.0 (0.2-5.9)

AOR (95% CI)

1.5 (0.8-2.8)

1.1 (0.6-2.3)

1.7 (0.7-4.3)

-

17

    

Case/control

11/11

10/10

4/5

1/2

COR (95% CI)

1.5 (0.6-3.4)

1.5 (0.6-3.5)

1.2 (0.3-4.4)

0.7 (0.1-8.1)

AOR (95% CI)

1.0 (0.4-2.4)

1.0 (0.4-2.6)

0.9 (0.2-3.4)

-

19

    

Case/control

6/5

3/4

2/2

0/0

COR (95% CI)

1.8 (0.5-5.8)

1.1 (0.2-4.9)

1.5 (0.2-10.4)

-

AOR (95% CI)

1.3 (0.4-4.2)

0.9 (0.2-4.1)

-

-

Current analysis

 

PCE EXPOSURE LEVEL

Latency period (years)

< Median

>Median

>75th Percentile

>90th Percentile

0

    

Case/control

224/324

225/324

123/162

56/64

COR (95% CI)

1.0 (0.8-1.2)

1.0 (0.8-1.2)

1.1 (0.8-1.4)

1.2 (0.8-1.8)

AOR (95% CI)

0.9 (0.8-1.2)

1.0 (0.8-1.3)

1.1 (0.9-1.5)

1.3 (0.9-1.9)

5

    

Case/control

193/276

206/276

104/138

53/55

COR (95% CI)

1.0 (0.8-1.2)

1.0 (0.8-1.3)

1.0 (0.8-1.4)

1.3 (0.9-2.0)

AOR (95% CI)

0.9 (0.7-1.2)

1.1 (0.9-1.4)

1.1 (0.8-1.5)

1.4 (0.9-2.1)

7

    

Case/control

176/248

189/248

101/124

51/49

COR (95% CI)

1.0 (0.8-1.3)

1.0 (0.8-1.3)

1.1 (0.8-1.5)

1.5 (1.0-2.2)

AOR (95% CI)

1.0 (0.8-1.3)

1.1 (0.9-1.4)

1.1 (0.8-1.5)

1.4 (0.9-2.2)

9

    

Case/control

148/218

171/218

89/109

47/43

COR (95% CI)

1.0 (0.7-1.2)

1.1 (0.9-1.4)

1.1 (0.8-1.5)

1.5 (1.0-2.4)

AOR (95% CI)

1.0 (0.7-1.2)

1.1 (0.8-1.3)

1.1 (0.8-1.5)

1.4 (0.9-2.2)

11

    

Case/control

122/188

159/188

75/94

40/37

COR (95% CI)

0.9 (0.7-1.2)

1.2 (0.9-1.5)

1.1 (0.8-1.5)

1.5 (1.0-2.5)

AOR (95% CI)

0.9 (0.7-1.2)

1.1 (0.8-1.4)

1.0 (0.7-1.4)

1.4 (0.9-2.4)

13

    

Case/control

106/163

136/162

73/81

37/32

COR (95% CI)

0.9 (0.7-1.2)

1.2 (0.9-1.5)

1.2 (0.9-1.7)

1.7 (1.0-2.7)

AOR (95% CI)

0.9 (0.7-1.2)

1.0 (0.8-1.4)

1.1 (0.8-1.6)

1.5 (0.9-2.5)

15

    

Case/control

85/115

101/114

50/57

20/22

COR (95% CI)

1.0 (0.8-1.4)

1.2 (0.9-1.6)

1.2 (0.8-1.8)

1.3 (0.7-2.4)

AOR (95% CI)

1.0 (0.7-1.3)

1.0 (0.7-1.3)

1.0 (0.7-1.5)

1.0 (0.5-1.9)

17

    

Case/control

61/71

69/70

31/35

18/14

COR (95% CI)

1.2 (0.8-1.7)

1.3 (0.9-1.9)

1.2 (0.7-2.0)

1.7 (0.8-3.5)

AOR (95% CI)

0.9 (0.6-1.3)

1.0 (0.7-1.5)

0.9 (0.5-1.5)

1.3 (0.6-2.7)

19

    

Case/control

34/40

50/38

19/19

9/7

COR (95% CI)

1.1 (0.7-1.8)

1.8 (1.1-2.7)

1.3 (0.7-2.6)

1.7 (0.6-4.7)

AOR (95% CI)

0.8 (0.5-1.3)

1.3 (0.8-2.0)

1.0 (0.5-2.0)

1.3 (0.5-3.6)

  1. Note: Referent group in the prior analysis was comprised of never exposed cases (n = 739) and controls (n = 1,085). The referent group in the current analysis was comprised of never exposed cases (n = 471) and controls (n = 645). Both adjusted analyses controlled for age at diagnosis or index year, vital status at interview, family history of breast cancer, personal history of breast cancer (before current diagnosis or index year), age at first live birth or stillbirth, occupational exposure to PCE, and study of origin.