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Table 6 Association between breast cancer and high cumulative PCE exposure: comparison of various cut points

From: Risk of breast cancer following exposure to tetrachloroethylene-contaminated drinking water in Cape Cod, Massachusetts: reanalysis of a case-control study using a modified exposure assessment

Latency period (years)

Prior Analysis >90th Percentile

Current Analysis >90th Percentile

Current Analysis Smoothing

0

   

RDD

41.8

19.5

35

Case/control

18/21

56/64

26/32

COR (95% CI)

1.3 (0.7-2.4)

1.2 (0.8-1.8)

1.1 (0.7-1.9)

AOR (95% CI)

1.3 (0.7-2.6)

1.3 (0.9-1.9)

1.3 (0.7-2.3)

5

   

RDD

41.7

20.6

35

Case/control

17/16

53/55

24/30

COR (95% CI)

1.6 (0.8-3.1)

1.3 (0.9-2.0)

1.1 (0.6-1.9)

AOR (95% CI)

1.5 (0.7-3.0)

1.4 (0.9-2.1)

1.3 (0.7-2.3)

7

   

RDD

40.9

19.0

35

Case/control

17/13

51/49

23/25

COR (95% CI)

1.9 (0.9-4.0)

1.5 (1.0-2.2)

1.3 (0.7-2.3)

AOR (95% CI)

1.7 (0.8-3.6)

1.4 (0.9-2.2)

1.4 (0.7-2.5)

9

   

RDD

38.4

17.4

35

Case/control

16/11

47/43

21/19

COR (95% CI)

2.1 (1.0-4.6)

1.5 (1.0-2.4)

1.6 (0.8-3.0)

AOR (95% CI)

1.9 (0.8-4.4)

1.4 (0.9-2.2)

1.6 (0.8-3.0)

11

   

RDD

37.3

16.1

35

Case/control

12/8

40/37

17/14

COR (95% CI)

2.2 (0.9-5.4)

1.5 (1.0-2.5)

1.8 (0.8-3.6)

AOR (95% CI)

1.8 (0.7-4.8)

1.4 (0.9-2.4)

1.8 (0.8-3.9)

13

   

RDD

36.8

12.8

35

Case/control

8/5

37/32

13/10

COR (95% CI)

2.3 (0.8-7.2)

1.7 (1.0-2.7)

1.9 (0.8-4.6)

AOR (95% CI)

1.7 (0.5-5.2)

1.5 (0.9-2.5)

2.0 (0.8-4.8)

15

   

RDD

49.1

14.0

35

Case/control

2/3

20/22

8/5

COR (95% CI)

1.0 (0.2-5.9)

1.3 (0.7-2.4)

2.1 (0.7-6.6)

AOR (95% CI)

-

1.0 (0.5-1.9)

1.8 (0.6-5.6)

17

   

RDD

40.6

11.4

35

Case/control

1/2

18/14

4/5

COR (95% CI)

0.7 (0.1-8.1)

1.7 (0.8-3.5)

1.1 (0.3-4.0)

AOR (95% CI)

-

1.3 (0.6-2.7)

-

19

   

RDD

169.9

9.5

35

Case/control

0/0

9/7

0/2

COR (95% CI)

-

1.7 (0.6-4.7)

-

AOR (95% CI)

-

1.3 (0.5-3.6)

-

  1. Note: The referent group was comprised of never exposed cases (n = 471) and controls (n = 645). The adjusted analysis controlled for age at diagnosis or index year, vital status at interview, family history of breast cancer, personal history of breast cancer (before current diagnosis or index year), age at first live birth or stillbirth, occupational exposure to PCE, and study of origin.