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Table 6 Association between breast cancer and high cumulative PCE exposure: comparison of various cut points

From: Risk of breast cancer following exposure to tetrachloroethylene-contaminated drinking water in Cape Cod, Massachusetts: reanalysis of a case-control study using a modified exposure assessment

Latency period (years) Prior Analysis >90th Percentile Current Analysis >90th Percentile Current Analysis Smoothing
0    
RDD 41.8 19.5 35
Case/control 18/21 56/64 26/32
COR (95% CI) 1.3 (0.7-2.4) 1.2 (0.8-1.8) 1.1 (0.7-1.9)
AOR (95% CI) 1.3 (0.7-2.6) 1.3 (0.9-1.9) 1.3 (0.7-2.3)
5    
RDD 41.7 20.6 35
Case/control 17/16 53/55 24/30
COR (95% CI) 1.6 (0.8-3.1) 1.3 (0.9-2.0) 1.1 (0.6-1.9)
AOR (95% CI) 1.5 (0.7-3.0) 1.4 (0.9-2.1) 1.3 (0.7-2.3)
7    
RDD 40.9 19.0 35
Case/control 17/13 51/49 23/25
COR (95% CI) 1.9 (0.9-4.0) 1.5 (1.0-2.2) 1.3 (0.7-2.3)
AOR (95% CI) 1.7 (0.8-3.6) 1.4 (0.9-2.2) 1.4 (0.7-2.5)
9    
RDD 38.4 17.4 35
Case/control 16/11 47/43 21/19
COR (95% CI) 2.1 (1.0-4.6) 1.5 (1.0-2.4) 1.6 (0.8-3.0)
AOR (95% CI) 1.9 (0.8-4.4) 1.4 (0.9-2.2) 1.6 (0.8-3.0)
11    
RDD 37.3 16.1 35
Case/control 12/8 40/37 17/14
COR (95% CI) 2.2 (0.9-5.4) 1.5 (1.0-2.5) 1.8 (0.8-3.6)
AOR (95% CI) 1.8 (0.7-4.8) 1.4 (0.9-2.4) 1.8 (0.8-3.9)
13    
RDD 36.8 12.8 35
Case/control 8/5 37/32 13/10
COR (95% CI) 2.3 (0.8-7.2) 1.7 (1.0-2.7) 1.9 (0.8-4.6)
AOR (95% CI) 1.7 (0.5-5.2) 1.5 (0.9-2.5) 2.0 (0.8-4.8)
15    
RDD 49.1 14.0 35
Case/control 2/3 20/22 8/5
COR (95% CI) 1.0 (0.2-5.9) 1.3 (0.7-2.4) 2.1 (0.7-6.6)
AOR (95% CI) - 1.0 (0.5-1.9) 1.8 (0.6-5.6)
17    
RDD 40.6 11.4 35
Case/control 1/2 18/14 4/5
COR (95% CI) 0.7 (0.1-8.1) 1.7 (0.8-3.5) 1.1 (0.3-4.0)
AOR (95% CI) - 1.3 (0.6-2.7) -
19    
RDD 169.9 9.5 35
Case/control 0/0 9/7 0/2
COR (95% CI) - 1.7 (0.6-4.7) -
AOR (95% CI) - 1.3 (0.5-3.6) -
  1. Note: The referent group was comprised of never exposed cases (n = 471) and controls (n = 645). The adjusted analysis controlled for age at diagnosis or index year, vital status at interview, family history of breast cancer, personal history of breast cancer (before current diagnosis or index year), age at first live birth or stillbirth, occupational exposure to PCE, and study of origin.