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Table 3 Functional categories significantly over-represented in the up- or down-modulated genes at 35 days of age by the effects of in uter o exposure to high dose of BBP

From: In utero exposure to butyl benzyl phthalate induces modifications in the morphology and the gene expression profile of the mammary gland: an experimental study in rats

 

Function

GO

p-value

Up-modulated

metabolic process

GO:0008152,

6.71E-14

  

GO:0044238, GO:0006629, GO:0005975,

GO:0019538, GO:0006800, GO:0006807,

GO:0006519, GO:0006732, GO:0006091,

GO:0006766, GO:0006790, GO:0022904

 
 

cell communication

GO:0007154

1.04E-09

 

signaling

GO:0007165

2.78E-09

  

GO:0007242, GO:0007267, GO:0007166

 
 

transport

GO:0006810

5.14E-09

  

GO:0006886, GO:0015031, GO:0006897,

GO:0006869, GO:0016192, GO:0006811,

GO:0051180, GO:0008643, GO:0006812

 
 

immune system process

GO:0002376

4.12E-08

 

cellular process

GO:0009987

1.73E-07

 

cell adhesion

GO:0007155

4.50E-07

  

GO:0007160, GO:0016337

 
 

system process

GO:0003008

8.59E-07

  

GO:0050877, GO:0008015, GO:0007601,

GO:0007268

 
 

response to stimulus

GO:0050896

3.96E-05

  

GO:0009605, GO:0006950, GO:0009636

 
 

homeostatic process

GO:0042592

1.22E-04

  

GO:0007596,GO:0001678

 
 

developmental process

GO:0032502

5.03E-04

  

GO:0009948, GO:0007399, GO:0048731,

GO:0007398

 
 

apoptosis

GO:0006915

1.91E-03

Down-modulated

cellular process

GO:0009987

5.88E-18

 

metabolic process

GO:0008152

1.14E-17

  

GO:0044238, GO:0006139, GO:0019538,

GO:0005975, GO:0006091, GO:0022904

 
 

cell cycle

GO:0007049

6.21E-13

  

GO:0007067

 
 

cell communication

GO:0007154

2.02E-09

  

GO:0007269

 
 

intracellular signaling cascade

GO:0007242

1.39E-08

  

GO:0007165, GO:0007267, GO:0007166

 
 

cell motion

GO:0006928

8.25E-07

 

transport

GO:0006810

5.83E-06

  

GO:0008643, GO:0006886, GO:0015031,

GO:0016192

 
 

cellular component organization

GO:0016043

2.56E-05

  

GO:0006325, GO:0006996

 
 

apoptosis

GO:0006915

9.20E-05

  

GO:0043066

 
 

immune system process

GO:0002376

1.07E-04

 

developmental process

GO:0032502

5.31E-04

  

GO:0048731, GO:0007399, GO:0007398

 
 

cell adhesion

GO:0007155

5.75E-04

  

GO:0016337, GO:0007160

 
 

response to stimulus

GO:0050896

2.18E-03

  

GO:0006950

 
 

system process

GO:0003008

2.45E-03

  

GO:0050877, GO:0007601, GO:0007268

 
 

Other

GO:0000910

2.32E-03

  

GO:0007276

7.53E-03

  1. GO, Gene Ontology class.
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Environmental Health

ISSN: 1476-069X