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Table 3 Percentages of adolescents and "elderly" persons with risk alleles

From: Prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in Flanders: a cross sectional study

Gene Risk Allele Adolescents % with 1 risk allele Elderly % with 1 risk allele Adolescents % with 2 risk alleles Elderly % with 2 risk alleles Adolescents mean number of risk alleles Elderly mean number of risk alleles
Biotransformation Phase I
CYP1A2 -154C 32.3 36.8 7.3 7.0 0,468 0,509
CYP1A1 3801C 15.1 21.1 2.3 3.3 0,197 0,276
CYP1A1 462V 6.9 6.3% 0.0 0.0 0,069 0,063
CYP1A1 461N 7.6 7.8 0.5 0.0 0,085 0,078
CYP2E1 -70T 6.0 8.8 0.0 0.5 0,060 0,098
CYP3A4 -391G 6.0 5.8 1.1 0.5 0,083 0,068
Biotransformation Phase II
GSTM1 Del n.a.1 n.a.1 56.6 53.4 1,136 1,068
GSTT1 Del n.a.1 n.a.1 18.4 14.3 0,367 0,286
GSTP1 105V 52.3 47.4 16.8 10.5 0,859 0,684
GSTP1 114V 12.5 14.5 2.5 1.0 0,175 0,165
NAT2 114T 49.9 49.6 30.6 19.8 1,113 0,892
NAT2 197Q 39.9 42.9 8.8 6.5 0,576 0,559
NAT2 286E 3.9 5.5 0.0 0.3 0,039 0,060
DNA Repair
BRCA2 A-26 29.9 38.2 3.7 6.1 0,375 0,504
BRCA2 372H 46.2 41.5 9.4 10.6 0,657 0,628
XRCC1 R194 11.0 12.7 0.5 0.8 0,120 0,142
XRCC1 280H 9.7 9.4 0.5 0.3 0,108 0,099
XRCC3 241M 49.8 44.1 16.4 19.5 0,829 0,830
XPD 751Q 42.8 49.9 14.5 11.1 0,720 0,722
XPD 156R 43.7 51.9 24.6 19.7 0,933 0,914
APE1 148G 48.3 47.5 25.2 27.9 0,989 1,033
OGG1 326C 37.2 35.9 7.1 6.6 0,517 0,491
Oxidative Stresss
mnSOD 16A 51.7 51.3 22.4 24.1 0,968 0,995
CAT -262T 30.0 31.7 9.8 8.8 0,499 0,494
NQO1 187S 13.3 5.3 0.2 0.3 0,140 0,058
NQO1 139W 31.1 31.4 4.6 4.3 0,405 0,399
MPO G-463 32.0 36.8 4.6 4.0 0,411 0,449
GPX1 198L 41.6 43.2 7.6 8.8 0,570 0,608
  1. 1Not available