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Table 4 Numbers and percentage of adolescents and "elderly" persons with low versus high numbers of risk alleles

From: Prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in Flanders: a cross sectional study

  

Low sum of risk alleles1

High sum of risk alleles1

Chi-Square

Total

Adolescents

203 (48.6%)

215 (51.4%)

p = 0.002

 

Elderly

215 (59.4%)

147 (40.6%)

 

Biotransformation

Adolescents

196 (45.7%)

233 (54.3%)

p = 0.005

 

Elderly

204 (55.6%)

163 (44.4%)

 

Phase I

Adolescents

321 (73.8%)

114 (26.2%)

p = 0.223

 

Elderly

258 (69.9%)

111 (30.1%)

 

Phase II

Adolescents

190 (43.7%)

245 (56.3%)

p < 0.001

 

Elderly

233 (58.7%)

164 (41.3%)

 

Oxidative Stress

Adolescents

256 (59.5%)

174 (40.5%)

p = 0.348

 

Elderly

249 (62.7%)

148 (37.3%)

 

DNA Repair

Adolescents

233 (54.4%)

195 (45.6%)

p = 0.017

 

Elderly

247 (62.7%)

147 (37.3%)

 
  1. 1The cut-off point between low and high sum of risk alleles was based on the median number of risk alleles for each specific pathway. A high number of risk alleles was defined as: Total: > 17 risk alleles; Biotransformation:> 5 risk alleles; Phase I: > 1 risk allele; Phase II: > 4 risk alleles; Oxidative stress: > 4 risk alleles; DNA repair > 8 risk alleles.
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Environmental Health

ISSN: 1476-069X