Parameters | Cases | Controls | p value | ||||||
---|---|---|---|---|---|---|---|---|---|
 | N (n) | median | 95% CI | Min-max | N (n) | median | 95% CI | Min-max |  |
Demographic and lifestyle factors | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Age (years) | 31 (31) | 50 | 46.1; 56.7 | 29.0-80.0 | 115 (115) | 54 | 49.1; 53.5 | 18-66 | 0.34 |
≤ 50 | 17 (54.8%) |  |  |  | 37 (32.2%) |  |  |  |  |
51-55 | 3 (9.70%) | Â | Â | Â | 26 (22.6%) | Â | Â | Â | Â |
56-59 | 3 (9.70%) | Â | Â | Â | 17 (14.8%) | Â | Â | Â | Â |
≥ 60 | 8 (25.8%) |  |  |  | 35 (30.4%) |  |  |  |  |
   BMI (kg/m2) | 31 (13) | 26.9 | 24.0; 29.1 | 16.5-34.4 | 115 (115) | 26.4 | 26.4;27.2 | 16.6-43.4 | 0.69 |
<25 | 4 | 23.5 | 16.0; 22.3 | 16.5-25.0 | 42 | 23.0 | 21.7;23.0 | 16.1-25.0 | 0.84 |
25-29 | 8 | 27.6 | 26.6; 28.9 | 25.8-29.6 | 42 | 27.6 | 26.9;27.8 | 25.1-19.9 | 0.46 |
> 30 | 1 | 34.4 | - | - | 31 | 33.2 | 33.1; 35.9 | 30.3-43.4 | - |
   n-3/n-6 | 31 (29) | 0.5 | 0.4; 0.6 | 0.2-1.7 | 115 (115) | 0.5 | 0.5; 0.7 | 0.1-2.2 | 0.31 |
   Serum cotinine (ng/ml) | 31 (28) | 11.6 | 33.3; 140.0 | 0-600.0 | 115 (96) | 120 | 121.0; 188.0 | 0.0-799.0 | 0.052 |
   Smoking status | 31 (26) |  |  |  | 115 (115) |  |  |  | 0.77 |
Never | 5 (19.2%) | Â | Â | Â | 21 (18.3%) | Â | Â | Â | Â |
Former | 3(11.5%) | Â | Â | Â | 20 (17.4%) | Â | Â | Â | Â |
Current | 18 (69.2%) | Â | Â | Â | 74 (64.3%) | Â | Â | Â | Â |
Reproductive factors | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Total number of full term pregnancies | 31(16) | 2.0 | 1.7; 2.8 | 1-4 | 115 (89) | 3.0 | 3.2; 4.1 | 0.0-11.0 | <0.0001 |
   Ever breastfed | 31(17) |  |  |  | 115 (85) |  |  |  |  |
Yes (%) | 15 (88.2%) | Â | Â | Â | 76 (89.4%) | Â | Â | Â | 0.89 |
   Menopausal status | 31 (20) |  |  |  | 115 (89) |  |  |  |  |
Premenopausal (%) | 11 (55.0%) | Â | Â | Â | 16 (18.0%) | Â | Â | Â | 0.001 |
Postmenopausal (%) | 9 (45.0%) | Â | Â | Â | 73 (82.0%) | Â | Â | Â | 0.001 |
   Serum E2 (nmol/l) | 31(24)* | 0.09 | 0.09; 0.23 | 0.03-0.51 | 115(59) | 0.07 | 0.05; 0.16 | 0.01-1.59 | 0.10 |
Premenopausal | 8 | 0.24 | 0.12; 0.38 | 0.06-0.44 | 11 | 0.13 | 0.05; 0.55 | 0.03-1.59 | Â |
Postmenopausal | 8 | 0.07 | 0.01; 0.25 | 0.03-0.51 | 48 | 0.07 | 0.06; 0.08 | 0.01-0.17 | Â |