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Table 4 Odds ratios of breast cancer and 95% confidence intervals associated with PFCs and POPs among breast cancer patients and controls

From: Perfluorinated compounds are related to breast cancer risk in greenlandic inuit: A case control study

  Raw1 Raw2 Adjusted3
variables n OR p n OR p n OR p
  (controls/cases) (95% CI)   (controls/cases) (95% CI)   (controls/cases) (95% CI)  
POPs          
   PFOS (ng/ml) 98/31 1.01 (1.003; 1.02) 0.02 69/9 1.01(0.99; 1.03) 0.23 69/9 1.03 (1.001; 1.07) 0.05
   PFOA(ng/ml) 98/31 1.07 (0.88; 1.31) 0.50 69/7 0.94 (0.05; 1.38) 0.76 69/7 1.20 (0.77; 1.88) 0.43
   sumPFSA(ng/ml) 98/31 1.013 (1.002;1.023) 0.02 69/15 1.01(0.99; 1.02) 0.37 69/15 1.03(1.00; 1.05) 0.02
   sumPFCA(ng/ml) 98/31 1.05 (0.99; 1.11) 0.14 69/12 1.01(0.93; 1.10) 0.82 69/12 1.07(0.96; 1.18) 0.23
   Sum PCB (μg/kg lipid)* 115/30 1.00(1.00; 1.00) 0.35 115/30 1.00(1.00; 1.00) 0.35 115/30 1.00(1.00; 1.00) 0.35
   Sum OCP (μg/kg lipid)* 115/30 1.00(1.00; 1.00) 0.13 115/30 1.00(1.00; 1.00) 0.13 115/30 1.00(1.00; 1.00) 0.13
   Sum PCB+sum OCP (μg/kg lipid)* 115/30 1.00(1.00; 1.00) 0.19 115/30 1.00(1.00; 1.00) 0.19 115/30 1.00(1.00; 1.00) 0.19
   Sum PCB + sum OCP + sum PFSA + sum PFCA(ng/ml) 115/31 1.01(1.001; 1.014) 0.03 85/11 1.01(0.99; 1.02) 0.37 85/11 1.02(1.01; 1.04) 0.01
Metals          
   Se (μg/kg) 115/30 1.0 (0.998; 1.001) 0.61 96/27 0.99(0.998; 1.001) 0.51 96/27 0.999(0.99; 1.001) 0.47
Xenobiotic induced transactivities          
   XER(RLU/μg protein) 110/31 0.41(0.02; 7.50) 0.55 81/7 0.90 (0.001;663.8) 0.78 81/7 1.17(0.001; 1936) 0.97
XER < 1 23/8 28.9 (0.00; 301126) 0.48 11/3 9.49 (0.00;8.34e8) 0.81 11/3 0.00 (0.00; ∞) 0.65
XER > 1 87/23 0.09 (0.00; 23.8) 0.40 70/6 0.66(0.00; 9476) 0.93 70/6 1.85 (0.00; 79767) 0.91
   XERcomp (RLU/μg protein) 110/31 2.15 (0.09; 53.77) 0.64 81/7 0.53(0.00; 18980) 0.91 81/7 0.22(0.00; 1166) 0.73
XERcomp <1 40/9 0.67 (0.00.00; 436) 0.90 20/1 0 (0.00; ∞) 0.995 20/1 0.00 (0.000; ∞) 0.99
XERcomp >1 70/22 0.60 (0.00; 1142) 0.89 61/6 0.06(0.00; 56092) 0.67 61/6 0.00(0.000; 111.6) 0.12
   XAR(RLU/μg protein) 58/27 8.52 (1.55; 46.78) 0.01 49/11 28.5 (1.79; 452.6) 0.02 49/11 44.14(1.99; 975.7) 0.02
   XARcomp(RLU/μg protein) 58/27 0.70(0.09; 5.31) 0.73 47/7 4.27 (0.17; 106.7) 0.38 47/7 5.04(0.20; 130.3) 0.33
   AhR-TEQ(pg/g lipid) 113/29 0.99(0.99; 1.001) 0.09 83/6 1.003(0.98; 1.02) 0.77 83/6 1.01(0.98; 1.029) 0.58
  1. Raw1: unadjusted data of full number of samples. Raw2: unadjusted data for the subset having all the corresponding adjustment variables (age, BMI, pregnancy, cotinine, breastfeeding, menopausal status), Adjusted3: fully adjusted data for the corresponding confounders. OR: odds ratio. CI: confidence interval. For sum PFSA, sum PFCA, sum PCB, sum OCP see legend of Table 2. For XER, XERcomp, XAR, XARcomp and TEQ see legend of Table 3. *: not adjusted since no confounder was identified.