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Table 5 Regression Models of Genotypesa Predicting Log-transformedb Blood Manganese (μg/L)

From: Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models

 

Crude

Adjusted for Hemoglobin

Fully Adjustedc

Genotype

N

Beta

(95% CI)

N

Beta

(95% CI)

N

Beta

(95% CI)

HFE C282Y

330

-0.23

(-0.52 to 0.05)

327

-0.23

(-0.51 to 0.06)

324

-0.22

(-0.53 to 0.08)

HFE H63D

328

-0.09

(-0.20 to 0.03)

325

-0.08

(-0.20 to 0.03)

322

-0.08

(-0.20 to 0.03)

HFE d

331

-0.12

(-0.23 to -0.01)

328

-0.12

(-0.23 to -0.01)

325

-0.11

(-0.23 to -0.003)

TF P570S

329

0.01

(-0.10 to 0.12)

326

0.02

(-0.09 to 0.13)

323

0.02

(-0.10 to 0.13)

ALAD K59N

330

0.02

(-0.16 to 0.20)

327

-0.01

(-0.20 to 0.18)

324

-0.02

(-0.20 to 0.17)

  1. a All models compare blood manganese levels among women with any variant allele to levels among women with no variant allele
  2. b Blood manganese concentrations are transformed to their natural logarithms; beta coefficients therefore represent percent change in manganese for carriers of variant alleles compared to women with no variant allele
  3. c Models adjusted for hemoglobin at 1-month postpartum and gestational age
  4. d C282Y or H63D