Table 1 Two types of cancer genes
“Strong” | “Weak” | |
|---|---|---|
Penetrance | High | Low |
Population frequency | Low | May be high |
Detectable by linkage analysis | Yes | No |
Detectable by LD analysis | Difficult | Possible |
Examples | Rb, BRCA1 | MDM2, TGFRB |
Overall contribution to cancer prevalence | Low | Could be high |