Table 2 Several low penetrance cancer genes are those involved in DNA repair. From Vineis et al. [38]

BRCA2

2

Breast

CCND1

2

Head & Neck

ERCC1

2

Bladder

ERCC2

53

Bladder; lung

ERCC4

6

Breast

ERCC5

2

Lung

MGMT

2

Prostate

NBN

4

Bladder

PARP1

2

Breast

POLI

3

Lung

TP53

115

Breast;cervix;lung

XPA

8

Lung

XRCC1

21

Cervix; esophageal, head & neck; skin; stomach

XRCC2

2

Colorectal

XRCC3

37

Breast; stomach

XRCC4

2

Bladder