Table 4 Some specific types of somatic mutations found in tumors. From Sjoblom et al., [27].
COLON | BREAST | TOTAL | ||
|---|---|---|---|---|
Substitutions at CG base pairs | CG to TA | 413 (59.3) | 289 (34.5) | 702 (45.8) |
CG to GC | 48 (6.9) | 239 (28.5) | 287 (18.7) | |
CG to AT | 93 (13.4) | 148 (17.7) | 241 (15.7) | |
Substitutions at TA base pairs | TA to CG | 56 (8.0) | 72 (8.6) | 128 (8.3) |
TA to GC | 51 (7.3) | 35 (4.2) | 86 (5.6) | |
TA to AT | 35 (5.0) | 55 (6.6) | 90 (5.9) | |
Substitutions at specific dinucleotides | 5’-CpG-3’ | 309 (44.4) | 139 (16.6) | 448 (29.2) |
5’-TpC-3’ | 79 (11.4) | 257 (30.7) | 336 (21.9) | |
TOTAL | 696 | 838 | 1534 | |