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Table 2 Adjusted Association Between Log-Transformed Phthalate Monoester Metabolites Urinary Concentrations and Sampling Conditions among French Pregnant Women From Eden and Pélagie Cohorts, 2002 – 2006 a

From: Correcting for the influence of sampling conditions on biomarkers of exposure to phenols and phthalates: a 2-step standardization method based on regression residuals

   DEHP metaboliteshh   MiBP   MBP   MCPP   MBzP   MEP   MCNP   MCOP
Sampling conditions n β P, p trend   β P, p trend   β P, p trend   β P, p trend   β P, p trend   β P, p trend   β P, p trend   β P, p trend
Hour of sampling 191   .02f, > .01g   .29 f, .08g   > 0.01f ,g   .04 f, .03g   .06 f, .13g   .66 f, .71g   .12 f, .22g   .32 f, .16g
  > 7.00 AM 36 0   0   0   0   0   0   0   0  
  7.00 to 7.59 AM 75 0.00 0.99 − 0.18 0.44 − 0.29 0.22 0.04 0.86 0.33 0.28 − 0.29 0.24 0.26 0.30 0.08 0.73
  8.00 to 9.59 AM 59 − 0.39 0.09 − 0.27 0.31 − 0.51 0.05 − 0.08 0.71 − 0.09 0.78 − 0.21 0.46 − 0.16 0.58 − 0.20 0.39
  After 10.00 AM 21 − 0.80 0.03 − 0.63 0.06 − 1.08 > 0.01 − 0.88 > 0.01 − 0.68 0.09 − 0.11 0.77 − 0.53 0.29 − 0.39 0.23
  Continuous b   − 0.09 0.04 − 0.06 0.22 − 0.20 > 0.01 − 0.10 0.02 − 0.09 0.09 − 0.03 0.62 − 0.12 0.05 − 0.09 0.05
Creatinine(g/l)c 287 1.1 > 0.01 0.98 > 0.01 0.96 > 0.01 0.95 > 0.01 1.2 > 0.01 0.96 > 0.01 0.76 > 0.01 0.91 > 0.01
Gestational age (weeks)
 Pélagie cohort 96   .92 f, .56g   .61 f, .34g   .74 f, .52g   .02 f, .52g   .28 f, .24g   .23 f, .47g   .29 f, .11g   .48 f, .36g
  6-10 24 0   0   0   0   0   0   0   0  
  10-12 20 0.03 0.94 − 0.009 0.98 0.16 0.60 0.82 0.01 − 0.27 0.45 − 0.26 0.56 − 0.24 0.47 0.31 0.42
  12-14 41 0.06 0.84 0.37 0.29 0.33 0.28 0.21 0.48 0.26 0.44 0.35 0.27 − 0.29 0.38 − 0.10 0.78
  14-19 11 0.29 0.56 0.10 0.75 0.06 0.87 − 0.04 0.91 0.22 0.63 − 0.20 0.60 − 0.76 0.07 − 0.20 0.62
  Continuous d   − 0.01 0.76 0.02 0.67 0.01 0.74 − 0.008 0.84 0.05 0.36 0.03 0.54 − 0.07 0.17 − 0.04 0.42
 Eden cohort 191   .50 f, .30g   .25 f, .58g   .14 f, .09g   .18 f, .08g   .01 f, .43g   .67 f, .95g   .15 f, .36g   .63 f, .38g
  24-25 25 0   0   0   0   0   0   0   0  
  25-27 87 − 0.06 0.75 − 0.27 0.23 0.01 0.97 0.05 0.82 − 0.58 0.03 − 0.22 0.44 − 0.20 0.57 − 0.02 0.94
  27-30 79 0.13 0.48 − 0.01 0.96 0.38 0.21 0.33 0.14 − 0.06 0.84 − 0.10 0.74 0.15 0.68 0.14 0.49
  Continuous d   0.03 0.55 0.04 0.50 0.14 0.04 0.11 0.07 0.07 0.35 − 0.007 0.93 0.07 0.35 0.02 0.79
Day of sampling 287   0.31 f   0.40 f   0.96 f   0.61 f   0.18 f   0.11 f   0.05 f   0.44 f
  Monday 57 0   0   0   0   0   0   0   0  
  Tuesday 69 − 0.37 0.14 − 0.17 0.42 0.04 0.86 − 0.11 0.54 0.02 0.93 − 0.02 0.92 − 0.29 0.19 − 0.20 0.33
  Wednesday 65 − 0.10 0.64 − 0.27 0.11 − 0.0005 0.99 − 0.24 0.20 − 0.06 0.81 − 0.04 0.88 − 0.45 0.02 − 0.39 0.03
  Thursday 48 − 0.33 0.13 − 0.18 0.39 − 0.14 0.49 − 0.36 0.11 − 0.11 0.60 − 0.22 0.36 − 0.10 0.73 − 0.30 0.17
  Friday 34 − 0.28 0.25 − 0.40 0.04 0.14 0.61 − 0.10 0.73 − 0.53 0.04 − 0.25 0.38 − 0.45 0.02 − 0.47 0.08
  Saturday 7 − 0.41 0.17 − 0.04 0.88 0.05 0.85 − 0.42 0.19 0.06 0.85 − 0.92 > 0.01 − 0.63 0.03 − 0.57 0.16
  Sunday 7 0.17 0.46 0.17 0.64 − 0.19 0.57 − 0.40 0.21 0.42 0.22 − 0.47 0.20 − 0.18 0.48 − 0.38 0.22
Season of sampling 287   0.54 f   0.34 f   0.92 f   0.86 f   0.52 f   0.84 f   0.81 f   0.98 f
  Jan-March 83 0   0   0   0   0   0   0   0  
  April-June 80 − 0.05 0.79 − 0.12 0.49 0.08 0.65 − 0.10 0.55 − 0.06 0.75 − 0.12 0.56 0.005 0.98 0.07 0.70
  July-Sept 59 − 0.15 0.47 − 0.12 0.57 − 0.004 0.98 − 0.07 0.71 0.21 0.35 0.06 0.82 0.10 0.63 0.06 0.79
  Oct-Dec 65 − 0.33 0.15 − 0.38 0.07 0.12 0.62 − 0.17 0.42 − 0.17 0.52 − 0.07 0.76 − 0.10 0.65 0.03 0.90
Duration of urine storage at room temperature (hours) 287   .29 f, .30g   .38 f, .29g   .82 f, .66g   .83 f, .58g   .30 f, .27g   .51 f, .95g   .85 f, .97g   .24 f, .38g
  ≤ 3 57 0   0   0   0   0   0   0   0  
  3-5 84 − 0.22 0.33 0.29 0.18 0.23 0.34 0.09 0.63 − 0.006 0.99 0.18 0.49 − 0.22 0.43 − 0.12 0.58
  6-24 94 − 0.01 0.96 0.13 0.58 0.16 0.57 0.21 0.36 − 0.09 0.80 − 0.21 0.57 − 0.20 0.57 − 0.23 0.39
  > 24 52 − 0.35 0.34 0.35 0.26 0.19 0.60 0.20 0.51 0.39 0.38 0.0005 0.99 − 0.05 0.91 0.21 0.55
  Continuous e   − 0.002 0.11 − 0.002 0.21 − 0.002 0.05 0.0003 0.86 0.0007 0.69 0.0004 0.81 − 0.001 0.36 0.001 0.43
  1. We applied correction factors of 0.66 and 0.72 to the monoethyl phthalate (MEP) and monobenzyl phthalate (MBzP) concentrations, respectively, because the analytic standards used were of inadequate purity.
  2. a Linear regression models were corrected for over-representation of cases and adjusted for maternal age, BMI, parity, centre, education, occupation and urine sampling conditions.
  3. b Regression parameters are given for an increase by 1 in the sampling hour.
  4. c Regression parameters are given for an increase by 1 g/l in urinary creatinine concentration.
  5. d Regression parameters are given for an increase by 1 week.
  6. e Regression parameters are given for an increase by 1 hour.
  7. f P of heterogeneity test.
  8. g P of trend test based on the indicated categories.
  9. h DEHP metabolites: MEHHP + MEOHP + MECPP + MEHP.