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Table 4 Phthalates Metabolites and Phenols Urinary Concentrations Among Pregnant Women From Eden and Pélagie Cohorts, France, 2002-2006

From: Correcting for the influence of sampling conditions on biomarkers of exposure to phenols and phthalates: a 2-step standardization method based on regression residuals

  

Correction/standardization applied to the biomarker concentrations

 
  

No correction

(Crude concentrations, μ g/l)a (1)

Case – control sampling only ( μ g/l)a (2)

Case – control sampling and creatinine

( μ g/g Cr)b (3)

Correction for case – control sampling and standardization for sampling conditions including creatinine c ( μ g/l)a (4)

Correction for case – control sampling and standardization for sampling conditions excluding creatinine d ( μ g/l)a (5)

Median change

(5 – 2)e

Correlation standardized – unstandardized (5)(2) f

Compound

n

Median

25th

75th

Median

25th

75th

Median

25th

75th

Median

25th

75th

Median

25th

75th

  

Phthalate monoester metabolites

  MEHHP + MEOHP + MECPP + MEHP ( μ mol/l)

287

0.36

0.18

0.62

0.37

0.17

0.61

0.32

0.19

0.53

0.53

0.29

0.86

0.58

0.32

1.06

+ 56%

0.94

  MiBP

287

50

29

97.5

45.9

30.2

84.0

45.7

28.0

71.9

59.2

39.0

101.5

64.7

41.2

119.3

+ 41%

0.94

  MBP

287

57.5

30.5

104

48.1

28.9

86.7

48.5

27.6

75.5

57.5

35.9

86.4

58.1

34.3

105.6

+ 21%

0.96

  MCCP

287

2.40

1.40

4.80

2.20

1.30

4.30

1.93

1.37

3.20

2.74

1.76

4.91

3.15

1.69

5.54

+ 43%

0.94

  MBzP

287

18.5

10.4

40.3

17.7

9.3

33.5

16.0

8.6

28.0

20.4

9.7

42.9

21.7

9.6

57.7

+23%

0.88

  MEP

287

112

49.0

236

110

53.3

215

106

54.4

198

103

58.7

196

105

53.9

240

− 5%

0.95

  MCNP

287

1.90

1.10

3.40

1.70

1.10

3.00

1.59

1.15

2.51

2.89

2.05

5.00

3.06

1.89

5.63

+80%

0.95

  MCOP

287

3.10

1.50

6.20

2.70

1.40

5.10

2.37

1.44

4.58

3.81

2.04

7.39

3.89

2.12

7.93

+44%

0.93

Phenols

                  

  2,4-DCP

191

0.90

0.50

1.60

0.90

0.50

1.50

0.78

0.51

1.48

0.78

0.47

1.51

0.77

0.49

1.59

− 14%

0.98

  2,5-DCP

191

10.30

4.10

26.8

10.2

4.10

26.50

8.88

4.27

24.4

6.73

3.08

23.3

6.37

2.92

25.6

− 38%

0.95

Sum of Parabens ( μ mol/l)

191

0.90

0.28

2.36

0.86

0.27

2.45

0.81

0.29

2.15

0.86

0.30

2.31

0.95

0.29

2.32

+10%

0.98

  BP3

191

1.60

0.60

4.10

1.70

0.70

4.40

1.63

0.64

4.19

1.13

0.59

3.87

1.30

0.54

4.04

− 24%

0.96

  BPA

191

2.80

1.60

4.90

2.70

1.70

5.50

2.50

1.62

4.49

3.06

1.80

5.26

3.11

1.92

6.11

+15%

0.95

  Triclosan

191

24.8

4.0

174

24.1

3.80

173

26.7

3.20

168.1

18.1

2.50

96.2

17.5

2.62

101.1

− 27%

0.99

  1. We applied correction factors of 0.66 and 0.72 to the monoethyl phthalate (MEP) and monobenzyl phthalate (MBzP) concentrations, respectively, because the analytic standards used were of inadequate purity.
  2. a For metabolites of DEHP and sum of parabens, concentrations are reported in μ mol/l.
  3. b For metabolites of DEHP and sum of parabens, corrected concentrations are reported in μ mol/g Creatinine. Correction for creatinine was performed by dividing biomarker concentrations by creatinine concentration.
  4. c Results corrected for over-representation of cases according to Richardson et al. (2007) and standardized for all sampling conditions (including creatinine) using formula (1) in the methods section.
  5. d Results corrected for over-representation of cases according to Richardson et al. (2007) and standardized for sampling conditions (excluding creatinine) using formula (1) in the methods section.
  6. e Relative changes in the median concentration of urinary biomarkers between the estimates of column (5) and (2).
  7. f Coefficient of correlation (Pearson) between non-standardized biomarkers levels corrected for the case – control sampling and concentrations corrected for the case – control sampling and standardized for all sampling conditions excluding creatinine.
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Environmental Health

ISSN: 1476-069X