Table 3 Odds of bladder cancer by genotype in genes of interest (Adjusted Odds Ratios and 95% Confidence Intervals)
SNP | Genotype | Cases N (%) | Controls N (%) | Age and smoking-adjusted OR (95% CI) |
|---|---|---|---|---|
GSTO-1 | ||||
rs4925 | C/C | 97 (44.7) | 123 (46.1) | 1.00 |
C/A | 98 (45.2) | 113 (42.3) | 1.14 (0.77 – 1.68) | |
A/A | 17 (7.8) | 30 (11.2) | 0.82 (0.42 – 1.61) | |
C/C | 1.00 | |||
C/A & A/A | 1.07 (0.74 – 1.56) | |||
rs2282326 | A/A | 84 (39.1) | 104 (38.5) | 1.00 |
A/C | 97 (44.3) | 122 (45.2) | 1.03 (0.68 – 1.55) | |
C/C | 34 (15.8) | 44 (16.3) | 1.07 (0.61 – 1.86) | |
A/A | 1.00 | |||
A/C & C/C | 1.04 (0.71 – 1.52) | |||
As3MT | ||||
rs1046778 | T/T | 112 (52.1) | 134 (49.3) | 1.00 |
T/C | 80 (37.2) | 113 (41.5) | 0.83 (0.56 – 1.24) | |
C/C | 23 (11.4) | 25 (9.2) | 1.00 (0.53 – 1.91) | |
T/T | 1.00 | |||
T/C & C/C | 0.87 (0.60 – 1.26) | |||
rs3740400 | A/A | 80 (37.0) | 113 (41.7) | 1.00 |
A/C | 118 (54.6) | 122 (45.0) | 1.34 (0.90 – 2.00) | |
C/C | 18 (8.3) | 36 (13.3) | 0.71 (0.37 – 1.36) | |
A/A | 1.00 | |||
A/C & C/C | 1.20 (0.82 – 1.75) | |||
rs11191439 | T/T | 172 (80.0) | 222 (82.2) | 1.00 |
T/C | 39 (18.1) | 46 (17.0) | 1.12 (0.69 – 1.82) | |
C/C | 4 (1.9) | 2 (0.7) | 2.75 (0.47 – 16.77) | |
T/T | ||||
T/C & C/C | 1.18 (0.74 – 1.90) | |||
rs11191438 | G/G | 71 (32.7) | 103 (37.9) | 1.00 |
G/C | 113 (52.1) | 122 (44.9) | 1.26 (0.84 – 1.90) | |
C/C | 33 (15.2) | 47 (17.3) | 1.00 (0.57 – 1.74) | |
G/G | 1.00 | |||
G/C & C/C | 1.19 (0.81 – 1.76) | |||
rs7085104 | A/A | 86 (39.5) | 119 (43.9) | 1.00 |
A/G | 112 (51.4) | 120 (44.3) | 1.28 (0.87 – 1.90) | |
G/G | 20 (9.2) | 32 (11.8) | 0.88 (0.46 – 1.68) | |
A/A | ||||
A/G & G/G | 1.20 (0.82 – 1.74) | |||
MTHFR | ||||
rs1801131 | A/A | 95 (43.6) | 127 (46.7) | 1.00 |
C/A | 109 (50.0) | 111 (40.8) | 1.39 (0.94 – 2.05) | |
C/C | 14 (6.4) | 34 (12.5) | 0.55 (0.28 – 1.11) | |
A/A | 1.00 | |||
C/A & C/C | 1.19 (0.82 – 1.72) | |||
rs1801133 | C/C | 92 (42.0) | 121 (44.3) | 1.00 |
C/T | 106 (48.4) | 121 (44.3) | 1.18 (0.80 – 1.75) | |
T/T | 21 (9.6) | 31 (11.4) | 0.86 (0.45 – 1.62) | |
C/C | 1.00 | |||
C/T & T/T | 1.11 (0.77 – 1.62) | |||
rs6541003 | A/A | 69 (31.7) | 89 (32.8) | 1.00 |
A/G | 125 (57.3) | 131 (48.3) | 1.36 (0.91 – 2.10) | |
G/G | 24 (11.0) | 51 (18.8) | 0.65 (0.36 – 1.18) | |
A/A | 1.00 | |||
A/G & G/G | 1.17 (0.79 – 1.75) | |||
rs9651118 | T/T | 138 (63.0) | 180 (65.9) | 1.00 |
C/T | 68 (31.1) | 83 (30.4) | 1.03 (0.69 – 1.54) | |
C/C | 13 (5.9) | 10 (3.7) | 1.54 (0.63 – 3.71) | |
T/T | 1.00 | |||
C/T & C/C | 1.08 (0.74 – 1.59) | |||
rs4846048 | A/A | 102 (47.0) | 131 (49.2) | 1.00 |
A/G | 100 (46.1) | 111 (40.8) | 1.25 (0.85 – 1.85) | |
G/G | 15 (6.9) | 30 (11.0) | 0.66 (0.33 – 1.32) | |
A/A | ||||
A/G & G/G | 1.12 (0.78 – 1.63) | |||
rs1476413 | G/G | 120 (55.1) | 139 (51.3) | 1.00 |
G/A | 88 (40.4) | 105 (38.8) | 1.01 (0.69– 1.49) | |
A/A | 10 (4.6) | 27 (10.0) | 0.40 (0.18 – 0.88) | |
G/G | 1.00 | |||
G/A & A/A | 0.88 (0.61 – 1.27) |