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Table 1 Toxic effects of methyl bromide (data 1990-2011)

From: Prostate cancer and toxicity from critical use exemptions of methyl bromide: Environmental protection helps protect against human health risks

Effect observed Ref.
in vitro  
chromosomal aberration (mammalian cells exposed to gaseous methyl bromide) [54]
Sister chromatid exchange and chromosome aberrations in lymphocytes  
O-6-alkylguanine-DNA-alkyltransferase [49]
genotoxic in bacteria (Ames test) [23]
Genotoxicity in workers exposed to methyl bromide [88]
in vivo  
toxic encephalopathies (animal experiments) [65]
immunoreactive HSP 70 in rat olfactory receptor neurone [64]
DNA methylation (rat, mice) [48]
reduction in the white blood cells (rat) [89]
increase in SCOT, SGPT activities (mice) [89]
hepatic and glomerular injuries (mice) [89]
MMP-9, matrix-metalloproteinase -9 and -2, MMP-2 expression in olfactory bulb following methal bromide gas exposure (mice) [66]
human  
irritation of eyes, skin, respiratory system; muscle weakness, coordination loss, visual disturbance, dizziness; nausea, vomiting, headache; malaise (vague feeling of discomfort); hand tremor; convulsions; dyspnea (breathing difficulty); skin vesiculation; liquor frostbite; [potential occupational carcinogen] [11, 34]
acute poisoning: ataxia, behavioral changes, seizures, coma chronic low level exposure: peripheral neuropathy, electroencephalogram abnormalities, deficits on the Wechsler memory scale (on 2-point discrimination at the index scale) [90]
headache, dizziness, nausea [11, 34]
chronic exposure: central and peripheral system disorders, cerebro-vestibular and pyramidal neuropathy of lower  
limbs, paresthesia
cerebro-vestibular and pyramidal neuropathy of lower limbs, paresthesis
 
motor neuron disease [16]
acute exposure (high concentration): refractory seizures, intermittent fever, multiorgan system failure, death [13]
liver degenerative changes [1]
reduction of lung function, chest pain, shortness of breath, inflammation of the lung [1]
erectile dysfunction [38]
central nervous system toxicity and early peripheral neuropathy following dermal exposure [36]
diffuse lesions in the spleen of the corpus callosum [91]