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Table 4 Odds ratios (ORs) and 95% confidence intervals (CIs) for the prevalence of hyperthyroidism associated with estimated nitrate levels in residential wells

From: Modeled nitrate levels in well water supplies and prevalence of abnormal thyroid conditions among the Old Order Amish in Pennsylvania

Overall

  

Men

 

Women

 

mg/L nitrate-nitrogen

Cases

OR 95%CI

Cases

OR 95%CI

Cases

OR 95%CI

Clinical Hyperthyroidism

   Low nitrate (< 6.5)

5

1.0

1

1.0

4

1.0

   High nitrate (= > 6.5)

5

0.95 (0.27-3.28)

2

1.85(0.17-20.7)

3

0.70 (0.16-3.15)

Subclinical Hyperthyroidism

   Low nitrate (< 6.5)

13

1.0

5

1.0

8

1.0

   High nitrate (= > 6.5)

12

0.86(0.39-1.91)

3

0.57 (0.13-2.38)

9

1.07 (0.41-2.79)

Subclinical Hyperthyroidism

   Q1 [0.34-4.46]

6

1.0

1

1.0

5

1.0

   Q2 [4.47-6.53]

7

1.14 (0.38-3.42)

4

4.01(0.45-36.2)

3

0.53 (0.14-2.47)

   Q3 [6.54-8.55]

8

1.29 (0.45-3.76)

2

1.98 (0.18-22.0)

6

1.17 (0.35-3.90)

   Q4 [8.56-16.4]

4

0.62 (0.18-2.23)

1

0.99 (0.06-15.9)

3

0.56 (0.13-2.38)

p-trend

 

0.36

 

0.25

 

0.65

  1. Models adjusted for age and BMI; model with men and women combined is also adjusted for gender