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Table 5 Odds ratios (ORs) and 95% confidence intervals (CIs) for the prevalence of hypothyroidism associated with nitrate levels in residential wells

From: Modeled nitrate levels in well water supplies and prevalence of abnormal thyroid conditions among the Old Order Amish in Pennsylvania

Overall    Men   Women  
mg/L nitrate-nitrogen Cases OR 95%CI Cases OR 95%CI Cases OR 95%CI
Clinical Hypothyroidism
   Low nitrate (< 6.5) 29 1.0 11 1.0 18 1.0
   High nitrate (= > 6.5) 27 0.89 (0.52-1.52) 12 0.98 (0.43-2.25) 15 0.82 (0.41-1.66)
Subclinical Hypothyroidism
   Low nitrate (< 6.5) 96 1.0 44 1.0 52 1.0
   High nitrate (= > 6.5) 132 1.32 (1.0-1.75) 49 0.98 (0.63-1.52) 83 1.60 (1.11-2.32)
Subclinical Hypothyroidism
   Q1 [0.34-4.46] 48 1.0 20 1.0 28 1.0
   Q2 [4.47-6.53] 49 0.99 (0.65-1.51) 24 1.06 (0.56-2.00) 25 0.93 (0.52-1.64)
   Q3 [6.54-8.55] 69 1.45 (0.97-2.15) 23 0.97 (0.51-1.83) 46 1.84 (1.11-3.06)
   Q4 [8.56-16.4] 62 1.23 (0.82-1.84) 26 1.12 (0.60-2.09) 36 1.28 (0.75-2.16)
p-trend   0.57   0.91   0.45
  1. Models adjusted for age and BMI; model with men and women combined is also adjusted for gender; nitrate concentrations in mg/L