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Table 5 Odds ratios (ORs) and 95% confidence intervals (CIs) for the prevalence of hypothyroidism associated with nitrate levels in residential wells

From: Modeled nitrate levels in well water supplies and prevalence of abnormal thyroid conditions among the Old Order Amish in Pennsylvania

Overall

  

Men

 

Women

 

mg/L nitrate-nitrogen

Cases

OR 95%CI

Cases

OR 95%CI

Cases

OR 95%CI

Clinical Hypothyroidism

   Low nitrate (< 6.5)

29

1.0

11

1.0

18

1.0

   High nitrate (= > 6.5)

27

0.89 (0.52-1.52)

12

0.98 (0.43-2.25)

15

0.82 (0.41-1.66)

Subclinical Hypothyroidism

   Low nitrate (< 6.5)

96

1.0

44

1.0

52

1.0

   High nitrate (= > 6.5)

132

1.32 (1.0-1.75)

49

0.98 (0.63-1.52)

83

1.60 (1.11-2.32)

Subclinical Hypothyroidism

   Q1 [0.34-4.46]

48

1.0

20

1.0

28

1.0

   Q2 [4.47-6.53]

49

0.99 (0.65-1.51)

24

1.06 (0.56-2.00)

25

0.93 (0.52-1.64)

   Q3 [6.54-8.55]

69

1.45 (0.97-2.15)

23

0.97 (0.51-1.83)

46

1.84 (1.11-3.06)

   Q4 [8.56-16.4]

62

1.23 (0.82-1.84)

26

1.12 (0.60-2.09)

36

1.28 (0.75-2.16)

p-trend

 

0.57

 

0.91

 

0.45

  1. Models adjusted for age and BMI; model with men and women combined is also adjusted for gender; nitrate concentrations in mg/L