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Table 6 Breast cancer odds ratios (matched analysis) with cumulative exposures, in major sectors and for derived hypotheses, and interactions with prior agricultural work, by conditional logistic regression

From: Breast cancer risk in relation to occupations with exposure to carcinogens and endocrine disruptors: a Canadian case–control study

Model/Parameter

OR (95% CI)

Wald P

Model 1

  

  Cumulative Exposure1 I (lagged 5 year)

1.29 (1.10-1.51)

0.0017

Model 2

  

  Cumulative Exposure2 II (lagged 5 year)

1.42 (1.18-1.73)

0.0003

Model 3

  

Farming

1.34 (1.03-1.74)

0.031

Non-plastic light mfg

0.83 (0.29-2.37)

0.73

Chemical, petrochemical

2.15 (0.0->100)

0.82

Plastics

2.43 (1.39-4.22)

0.0018

Metalworking

1.73 (1.02-2.92)

0.041

Transport

0.84 (0.28-2.52)

0.76

Beauty care/laundry/dry cleaning

1.02 (0.72-1.43)

0.92

Bars/gambling

2.20 (0.91-5.29)

0.078

Model 4

  

Farming: all

1.36 (1.01-1.82)

0.044

Farming: corn (since 1978)

0.76 (0.09-6.69)

0.80

Farming: greenhouse workers

1.04 (0.38-2.83)

0.94

Non-plastic light mfg

0.87 (0.30-2.50)

0.80

Chemical, petrochemical

1.47 (0.0->100)

0.91

Transport

0.80 (0.25-2.54)

0.71

Beauty care/laundry/dry cleaning

1.02 (0.72-1.43)

0.92

Bars/gambling

2.28 (0.94-5.53)

0.068

Auto industry: plastics

2.68 (1.47-4.88)

0.0013

Auto industry: small enterprises

2.48 (1.00-6.10)

0.051

Auto industry: large enterprises

1.18 (0.56-2.50)

0.66

Canning

2.35 (1.00-5.53)

0.050

Healthcare workers

1.01 (0.87-1.18)

0.89

Toll booth workers

1.17 (0.44-3.14)

0.76

Model 5

  

Farming: all

1.35 (1.00-1.82)

0.049

Farming: corn (since 1978)

0.64 (0.07-5.78)

0.69

Farming: greenhouse workers

0.95 (0.35-2.60)

0.92

Non-plastic light mfg

0.86 (0.30-2.49)

0.78

Chemical, petrochemical

1.56 (0.0->100)

0.90

Metalworking

1.71 (0.99-2.95)

0.055

Metalworkingl… IpAg

1.04 (0.89-1.21)

0.64

Transport

0.82 (0.27-2.55)

0.74

Beauty care/laundry/dry cleaning

1.03 (0.73-1.45)

0.87

Bars, gambling

1.79 (0.67-4.73)

0.24

Bars, gambling … IpAg

2.38 (0.58-9.79)

0.23

Auto industry: plastics

2.41 (1.31-4.44)

0.0048

Auto plastics… IpAg

2.31 (0.53-9.98)

0.26

Canning

1.90 (0.72-4.99)

0.19

Canning … IpAg

1.14 (0.83-1.56)

0.43

Healthcare workers

1.05 (0.89-1.24)

0.54

Healthcare… IpAg

0.96 (0.91-1.02)

0.20

Toll booth workers

1.17 (0.43-3.13)

0.76

  1. All five models include reproductive, demographic risk factors as in Table 4 and employment duration terms; IpAg, interaction with farming: cumulative (sector rating × prior cum. exposure in agriculture).
  2. Odds ratios (OR) evaluated at 10 years in high-exposed jobs (lagged 5 year) or, for interactions, at 10 years in high-exposed jobs and 1 year in prior high-exposed farm work; matching on age in 3-year intervals; for including employment duration terms: χ2 (2df) =10.9, p=0.025 (Model 4).
  3. 1. cumulative exposure on transformed ratings: 1 (low), 2 (moderate), 3 (high) → 0, 1, 2, as rating-year.
  4. 2. cumulative exposure on transformed ratings: 1 (low), 2 (moderate), 3 (high) → 0, 1, 10, as rating-year, except bars/gambling and toll booth workers (maximum rating = 1; no jobs rated high).
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Environmental Health

ISSN: 1476-069X