Skip to main content

Advertisement

Table 7 Breast cancer odds ratios for cumulative exposure accruing in time-windows reflecting reproductive status, by conditional multiple logistic regression

From: Breast cancer risk in relation to occupations with exposure to carcinogens and endocrine disruptors: a Canadian case–control study

Parameter   
Window OR (95% CI) Wald P
Cumulative Exposure 1 I   
< menarche 1.037 (0.89-1.21)  
menarche-first pregnancy 1.018 (0.98-1.06)  
first pregnancy – menopause 1.036 (1.01-1.06) 0.012
menopause - 1.012 (0.97-1.06)  
Cumulative Exposure 2 II   
< menarche 1.003 (0.85-1.18)  
menarche-first pregnancy 1.037 (0.98-1.09) 0.18
first pregnancy – menopause 1.050 (1.01-1.09) 0.0072
menopause - 1.018 (0.97-1.07)  
Selected cumulative exposures 2,3,4   
Farming   
< menarche 1.054 (0.88-1.26)  
menarche-first pregnancy 0.997 (0.93-1.07)  
first pregnancy – menopause 1.046 (0.98-1.12) 0.19
menopause - 1.054 (0.96-1.16)  
Bars, gambling   
menarche-first pregnancy 1.022 (0.81-1.29)  
first pregnancy – menopause 1.141 (0.98-1.33) 0.092
menopause - 1.039 (0.82-1.32)  
Metalworking   
menarche-first pregnancy 1.161 (0.96-1.40) 0.12
first pregnancy – menopause 1.064 (0.97-1.16) 0.17
menopause - 1.020 (0.92-1.13)  
Auto industry: plastics   
menarche-first pregnancy 1.297 (1.05-1.61) 0.018
first pregnancy – menopause 1.104 (1.01-1.20) 0.023
menopause - 1.044 (0.92-1.19)  
Canning   
menarche-first pregnancy 1.262 (0.96-1.66) 0.095
first pregnancy – menopause 1.079 (0.96-1.22)  
menopause - 1.041 (0.88-1.24)  
  1. All three models include reproductive, demographic risk factors as in Table 4 and employment duration; matching on age in 3-year intervals.
  2. OR for cumulative exposure evaluated at 1.0 year in time-window inhigh-exposed jobs (lagged 5 year).
  3. 1. cumulative exposure on transformed ratings: 1 (low), 2 (moderate),3 (high) → 0, 1, 2, as rating-year.
  4. 2. cumulative exposure on transformed ratings: 1 (low), 2 (moderate),3 (high) → 0, 1, 10, as rating-year.
  5. 3. model includes all major sector exposures;
  6. 4. no cases/controls with non-farm exposure in window: < menarche.