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Table 7 Breast cancer odds ratios for cumulative exposure accruing in time-windows reflecting reproductive status, by conditional multiple logistic regression

From: Breast cancer risk in relation to occupations with exposure to carcinogens and endocrine disruptors: a Canadian case–control study

Parameter

  

Window

OR (95% CI)

Wald P

Cumulative Exposure 1 I

  

< menarche

1.037 (0.89-1.21)

 

menarche-first pregnancy

1.018 (0.98-1.06)

 

first pregnancy – menopause

1.036 (1.01-1.06)

0.012

menopause -

1.012 (0.97-1.06)

 

Cumulative Exposure 2 II

  

< menarche

1.003 (0.85-1.18)

 

menarche-first pregnancy

1.037 (0.98-1.09)

0.18

first pregnancy – menopause

1.050 (1.01-1.09)

0.0072

menopause -

1.018 (0.97-1.07)

 

Selected cumulative exposures 2,3,4

  

Farming

  

< menarche

1.054 (0.88-1.26)

 

menarche-first pregnancy

0.997 (0.93-1.07)

 

first pregnancy – menopause

1.046 (0.98-1.12)

0.19

menopause -

1.054 (0.96-1.16)

 

Bars, gambling

  

menarche-first pregnancy

1.022 (0.81-1.29)

 

first pregnancy – menopause

1.141 (0.98-1.33)

0.092

menopause -

1.039 (0.82-1.32)

 

Metalworking

  

menarche-first pregnancy

1.161 (0.96-1.40)

0.12

first pregnancy – menopause

1.064 (0.97-1.16)

0.17

menopause -

1.020 (0.92-1.13)

 

Auto industry: plastics

  

menarche-first pregnancy

1.297 (1.05-1.61)

0.018

first pregnancy – menopause

1.104 (1.01-1.20)

0.023

menopause -

1.044 (0.92-1.19)

 

Canning

  

menarche-first pregnancy

1.262 (0.96-1.66)

0.095

first pregnancy – menopause

1.079 (0.96-1.22)

 

menopause -

1.041 (0.88-1.24)

 
  1. All three models include reproductive, demographic risk factors as in Table 4 and employment duration; matching on age in 3-year intervals.
  2. OR for cumulative exposure evaluated at 1.0 year in time-window inhigh-exposed jobs (lagged 5 year).
  3. 1. cumulative exposure on transformed ratings: 1 (low), 2 (moderate),3 (high) → 0, 1, 2, as rating-year.
  4. 2. cumulative exposure on transformed ratings: 1 (low), 2 (moderate),3 (high) → 0, 1, 10, as rating-year.
  5. 3. model includes all major sector exposures;
  6. 4. no cases/controls with non-farm exposure in window: < menarche.