Table 2 Genetic alterations occurring in environmentally induced lung cancer
From: Arsenic, asbestos and radon: emerging players in lung tumorigenesis
CNA* at Locus | Carcinogen | References |
|---|---|---|
1q21.1 | Arsenic | [37] |
2p21-p16 | Asbestos | |
Ch.5 | Asbestos | [112] CL |
5q35 | Asbestos | |
Ch.8 | Asbestos | [112] CL |
9p21.3 (CDKN2A) | Radon, Asbestos | |
12p12.1 (KRAS**) | Asbestos | [124] |
16p13.3 | Asbestos | [122] |
17p13.1 (TP53**) | Asbestos | [110] S |
Ch.19 | Asbestos | [112] CL |
19p13.3-13.1 | Asbestos | |
19q13.31 | Arsenic | [37] |
19q13.33 (SPIB, NR1H2, POLD1) | Arsenic | [37] |
22q12.3-q13.1 | Asbestos | [122] |
Xq28 | Asbestos | [120] |