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Table 3 Top 30 strongest SNPs interacting with occupational exposure to affect FEV 1

From: Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study

SNP

Chr

Position

Band

Gene

All1

All2

MAF

βSNP

PSNP

βinteraction

Pinteraction

rs9931086

16

84046105

q23.3

SLC38A8

A

C

0.19

27.70

2.53E-02

-214

1.16E-07*

rs11252277

10

4065704

p15.1

 

G

A

0.09

2.90

1.05E-01

-263

6.32E-07

rs3889785

4

165097529

q32.3

MARCH1

A

C

0.13

-2.02

1.69E-01

237

1.05E-06

rs7098287

10

4050329

p15.1

 

G

C

0.09

3.60

4.88E-02

-247

2.47E-06

rs32977

5

14119057

p15.2

 

A

G

0.06

5.50

7.38E-03

-310

3.98E-06

rs17508671

2

185491847

q32.1

ZNF804A

A

G

0.16

-0.27

8.32E-01

-173

4.45E-06

rs2544785

19

49085710

q13.33

SULT2B1

C

T

0.16

0.03

0.983642

172

4.57E-06

rs4234966

4

165078580

q32.3

MARCH1

C

G

0.12

-1.92

1.88E-01

217

6.35E-06

rs32978

5

14119645

p15.2

 

C

T

0.05

5.05

1.75E-02

-302

6.63E-06

rs32979

5

14119775

p15.2

 

T

C

0.05

5.05

1.75E-02

-302

6.63E-06

rs17645582

6

82797317

q14.1

 

C

T

0.07

-1.07

5.75E-01

208

6.89E-06

rs4932559

15

92133594

q26.1

 

A

G

0.36

-1.62

0.081898

132

7.10E-06

rs745926

2

120482057

q14.2

 

T

G

0.41

-1.13

2.24E-01

136

9.90E-06

rs1561577

15

89146968

q26.1

 

A

G

0.07

-3.17

0.104592

224

1.16E-05

rs6445707

3

54881562

p14.3

CACNA2D3

G

A

0.18

0.40

7.47E-01

166

1.17E-05

rs2544784

19

49085733

q13.33

SULT2B1

A

T

0.16

0.00

0.997879

161

1.25E-05

rs17110400

14

26276467

q12

 

C

T

0.09

-0.31

0.855973

265

1.53E-05

rs10231843

7

103884705

q22.2

 

C

G

0.27

-1.10

3.09E-01

160

1.64E-05

rs17430621

2

185492469

q32.1

ZNF804A

A

T

0.16

0.02

9.85E-01

-165

1.89E-05

rs163814

5

14122497

p15.2

 

C

T

0.05

5.43

1.16E-02

-285

1.94E-05

rs477920

1

74767844

p31.1

FPGT TNNI3K

A

G

0.17

0.23

8.55E-01

-183

2.04E-05

rs6972824

7

157473222

q36.3

PTPRN2

C

A

0.11

2.38

8.22E-02

-196

2.30E-05

rs6124623

20

42746332

q13.12

JPH2

C

G

0.14

1.34

3.00E-01

-172

2.34E-05

rs2832081

21

30152992

q21.3

 

C

A

0.31

-2.33

0.01353

137

2.36E-05

rs7356986

6

12301462

p24.1

 

G

A

0.11

-1.68

3.20E-01

202

2.36E-05

rs41328144

1

166319711

q24.1

 

C

T

0.13

-0.68

6.35E-01

155

2.54E-05

rs2803543

10

88301331

q23.2

 

G

A

0.10

-2.35

1.49E-01

224

2.90E-05

rs163813

5

14122154

p15.2

 

G

A

0.05

5.00

1.88E-02

-281

2.96E-05

rs17508706

2

185524591

q32.1

ZNF804A

G

A

0.16

-0.14

9.12E-01

-162

3.04E-05

rs4130671

7

119277137

q31.31

 

A

C

0.49

-1.37

1.27E-01

122

3.71E-05

  1. SNP-estimates are based on an additive model. Beta-estimates represent the increase or decrease FEV1 in mL.
  2. *Significant after Bonferroni correction for testing 300,709 SNPs (α = 1.66E-07).
  3. Chr: Chromosome; All1: allele1; All2: allele2.