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Table 4 Top 30 strongest SNPs interacting with occupational exposure to affect FEV 1 /FVC

From: Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study

SNP

Chr

Position

Band

Gene

All1

All2

MAF

βSNP

PSNP

βinteraction

Pinteraction

rs17051547

4

53421172

q12

 

C

A

0.13

-0.44

3.31E-02

2.84

2.86E-06

rs17051550

4

53425943

q12

 

C

G

0.11

-0.38

8.06E-02

2.91

6.01E-06

rs11671079

19

29900846

q12

LOC284395

G

A

0.46

-0.10

0.397666

1.55

8.65E-06

rs2804576

10

113775409

q25.2

 

A

G

0.13

0.34

9.56E-02

-2.83

1.01E-05

rs7314308

12

59684714

q14.1

 

G

A

0.19

0.65

5.43E-05

-2.09

1.20E-05

rs7297210

12

19630207

p12.3

AEBP2

T

C

0.40

0.18

2.22E-01

-1.62

1.53E-05

rs2655364

18

26229339

q12.1

 

T

A

0.46

-0.20

1.43E-01

1.76

1.55E-05

rs4322259

1

64339246

p31.3

ROR1

C

G

0.35

0.21

1.59E-01

-1.72

1.61E-05

rs1504108

18

26224965

q12.1

 

A

G

0.45

-0.20

1.56E-01

1.76

1.82E-05

rs2655360

18

26231390

q12.1

 

T

C

0.45

-0.20

1.54E-01

1.73

2.23E-05

rs987124

18

26217351

q12.1

 

G

A

0.46

-0.20

1.38E-01

1.71

2.54E-05

rs9878581

3

37969695

p22.2

CTDSPL

C

G

0.13

-0.37

6.85E-02

2.23

2.92E-05

rs10751811

10

1687171

p15.3

ADARB2

A

G

0.36

-0.17

2.46E-01

1.53

3.06E-05

rs6486961

12

19626815

p12.3

AEBP2

A

G

0.40

0.13

3.60E-01

-1.59

3.13E-05

rs6941466

6

168929950

q27

SMOC2

T

C

0.22

-0.21

2.54E-01

2.03

3.21E-05

rs7297431

12

19600232

p12.3

AEBP2

T

C

0.45

0.15

2.75E-01

-1.59

3.30E-05

rs10770501

12

19683476

p12.3

 

G

A

0.46

0.16

2.51E-01

-1.57

3.35E-05

rs537693

6

159662136

q25.3

FNDC1

G

A

0.12

-0.11

6.18E-01

2.28

3.36E-05

rs2173524

10

1687799

p15.3

ADARB2

T

G

0.35

-0.18

2.46E-01

1.51

3.41E-05

rs1105791

9

81179317

q21.31

 

C

A

0.19

-0.36

0.026841

1.91

3.83E-05

rs1875467

12

19622345

p12.3

AEBP2

C

A

0.46

0.13

3.43E-01

-1.54

4.06E-05

rs9888671

15

26277939

q12

LOC100128714

C

T

0.13

0.17

3.79E-01

2.01

4.09E-05

rs12141717

1

55388480

p32.3

 

G

A

0.29

-0.08

5.89E-01

1.80

4.24E-05

rs11595576

10

1688497

p15.3

ADARB2

T

C

0.36

-0.16

2.96E-01

1.53

4.32E-05

rs5996665

22

24469115

q11.23

CABIN1

G

A

0.08

0.35

8.54E-02

-2.65

4.41E-05

rs7078873

10

61787587

q21.2

ANK3

T

A

0.38

0.30

3.34E-02

-1.62

4.49E-05

rs4938871

11

57329402

q12.1

UBE2L6

C

A

0.26

-0.36

3.28E-02

1.90

4.63E-05

rs1885166

9

17610211

p22.2

SH3GL2

T

C

0.39

0.10

0.487458

-1.70

4.77E-05

rs10052266

5

6010711

p15.32

 

G

A

0.12

0.32

0.094656

-2.01

4.83E-05

rs2763249

6

168926062

q27

SMOC2

A

G

0.22

-0.21

2.38E-01

1.97

4.89E-05

  1. SNP-estimates are based on an additive model. Beta-estimates represent the increase or decrease FEV1/FVC in percentage.
  2. Chr: Chromosome; All1: allele1; All2: allele2.