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Table 3 Median (5 th , 95 th percentile) of the outcomes at baseline as well as according to each exposure scenario
| Biomarkers | Baseline | Sham filtration | Active filtration | ||||
|---|---|---|---|---|---|---|---|
| Day 0 | Day 2 | Day 7 | Day 14 | Day 2 | Day 7 | Day 14 | |
| MVF | 1.69 (1.07, 2.87) | 1.74 (1.22, 2.60) | 1.80 (1.30, 2.96) | 1.72 (1.38, 2.56) | 1.73 (1.20, 2.78) | 1.69 (1.27, 2.63) | 1.73 (1.32, 2.84) |
| Diastolic pressure, (mmHg) | 80 (70, 90) | 78 (60, 90) | 80 (70, 90) | 80 (60, 90) | 80 (65, 90) | 80 (60, 95) | 77.5 (60, 90) |
| Systolic pressure, (mmHg) | 130 (100, 150) | 120 (90, 150) | 120 (105, 140) | 120 (100, 150) | 125 (95, 140) | 120 (95, 150) | 120 (100, 140) |
| C-reactive protein (mg/L) | 0.8 (0.2, 4.9) | 0.9 (0.2, 3.6) | 0.9 (0.2, 5.5) | 0.9 (0.2, 4.5) | 0.9 (0.1, 4.7) | 1.0 (0.2, 5.1) | 0.9 (0.2, 4.3) |
| Hemoglobin (mmol/L) | 9.6 (7.8, 10.7) | 9.3 (8.0, 11.2) | 9.0 (7.9, 11.4) | 9.1 (7.9, 10.8) | 9.2 (8.0, 10.5) | 9.1 (8.0, 10.3) | 9.2 (7.6, 11.7) |
| Leukocytes (×109cells/L) | 5.6 (4.1, 8.3) | 5.9 (4.1, 7.6) | 5.6 (3.8, 8.3) | 5.1 (3.8, 8.8) | 5.7 (4.0, 8.1) | 5.5 (3.9, 8.9) | 5.8 (3.8, 7.8) |
| Lymphocytes (×109cells/L) | 1.9 (0.9, 3.5) | 1.8 (0.9, 3.4) | 2.0 (0.8, 3.5) | 1.9 (1.0, 3.2) | 2.1 (1.1, 3.0) | 2.0 (1, 3.6) | 1.9 (0.9, 3.0) |
| Monocytes (×109cells/L) | 0.6 (0.4, 0.9) | 0.6 (0.4, 0.8) | 0.6 (0.3, 0.9) | 0.6 (0.4, 0.9) | 0.6 (0.4, 0.9) | 0.6 (0.4, 0.9) | 0.6 (0.4, 0.9) |
| Granulocytes (×109cells/L) | 3.0 (2.0, 4.8) | 3.2 (1.9, 4.9) | 2.6 (1.8, 5.3) | 2.9 (1.9, 5.5) | 2.9 (1.7, 4.9) | 2.7 (1.8, 5.4) | 3.0 (1.7, 5.4) |
| CD31(%) | 93.8 (84.6, 97.9) | 92.9 (85.2, 98.0) | 93.6 (85.2, 98.1) | 91.5 (81.1, 96.9) | 94.3 (84.0, 97.9) | 93.1 (79.4, 97.9) | 92.0 (78.1, 97.9) |
| CD62L(%) | 60.0 (40.7, 86.0) | 63.6 (42.7, 79.0) | 62.9 (44.1, 76.8) | 61.9 (39.3, 77.9) | 62.4 (45.7, 75.3) | 60.7 (43.5, 80.7) | 62.4 (44.1, 81.4) |
| CD11b(%) | 33.7 (4.9, 63.7) | 39.6 (4.0, 69.9) | 41.8 (6.2, 76.2) | 37.8 (12.6, 65.8) | 41.5 (8.3,70.0) | 35.8 (10.0, 62.6) | 37.6 (6.7, 73.5) |
| CD49d(%) | 60.5 (30.0, 95.5) | 72.7 (32.4, 94.8) | 76.7 (33.8, 94.3) | 74.9 (32.6, 95.1) | 72.4 (45.3, 96.5) | 73.3 (30.7, 96.5) | 71.5 (39.2, 95) |
| FEV1/FVC | 0.72 (0.42, 1.20) | 0.66 (0.47, 1.17) | 0.74 (0.38, 1.20) | 0.72 (0.45, 1.37) | 0.74 (0.38, 1.20) | 0.73 (0.46, 1.43) | 0.73 (0.43, 1.18) |
| CC16 (ng/ml) | 4.2 (2.0, 8.8) | 3.5 (2.0, 9.4) | 3.6 (2.0, 9.3) | 4.0 (2.0, 8.36) | 3.6 (2.0, 8.6) | 4.3 (2.0, 10.7) | 3.9 (2.0, 10.2) |
| SPD (ng/mL) | 100.6 (42.0, 285) | 100.6 (46.1, 302.8) | 99.0 (51.2, 279.2) | 97.6 (46.2, 283.8) | 103.1 (42.6, 306.1) | 94.3 (43.3, 294.2) | 98.7 (50.9, 338.7) |
