Table 1 Summary of default assessment factors used in human health risk assessment (adapted from ECHA 2008)

Database adequacy

1-10

1-100

1

1-5

1

LOAEL to NOAEL

3-10

10

3

10

1-10

3-10

3

Severity of Effect

1-10

1

1-10

Duration of exposure

10

Sub-chronic to chronic

2

2-3

10

3

2

Sub-acute to sub-chronic

2–3

10

8

3

Sub-acute to chronic

6

6-7

50-100

24

6

Interspecies

10

10

10

10

10

Toxicokinetics

4.0

4

Allometric scaling

Mouse

7

7

7

Rat

4

4

4

Monkey

2

2 or 4

2

Dog

2

2

1.4

toxicodynamics

2.5

2-3

2.5

2.5

Intraspecies

10

10

5

10

25

10

10-16

10

Toxicokinetics

3.16

8

3–5

Toxicodynamics

3.16

3

3.16

Modifying factor

≤10