Skip to main content

Table 4 Quantitative evaluation on interspecies differences using only animal data

From: Dispelling urban myths about default uncertainty factors in chemical risk assessment – sufficient protection against mixture effects?

Substances dataset Dose metric Species Results Reference
190 chemicals TD50 Mouse and rat Median TD50Mouse/TD50Rat ratio = 2.4 [70]
    20% of ratios exceeded 10  
69 pesticides NOAEL Mouse, rat and dog NOAELRat /NOAELDog : 1.58 (0.99-2.24) [71]
    NOAELMouse /NOAELRat : 3.87 (2.24-6.32)  
    NOAELMouse /NOAELDog : 7.07 (3.53-13.42)  
Binary interspecies comparisons from dozens to over 500 agents Mostly LC50 Aquatic species Orders-within-Classes Extrapolation [72]
    Weighted mean of uncertainty factor (UF) prediction interval (PI): 26 (95% PI), 35 (99% PI)  
    Upper 95% UFs: 65 (95% PI), 88 (99% PI)  
184 substances NOAEL Mouse, rat, dog NOAELRat /NOAELDog : 1.3 (P95 =18.8) [49]
    NOAELMouse /NOAELRat : 4.2 (P95 = 73.9)  
    NOAELMouse / NOAELDog : 6.4 (P95 = 124.6)  
198 substances NOAEL Mouse, rat, dog NOAELRat /NOAELDog : 2.3 (P95 =27) [73]
    NOAELMouse /NOAELRat : 3.2 (P95 = 37)  
    NOAELMouse /NOAELDog : 5.9 (P95 = 50)  
217 substances LD50 Mouse, hamster, guinea pig, rat, cat, rabbit, monkey dog LD50Mouse/LD50Rat= 0.86 (P95 = 2.52)  
    LD50Hamster/LD50Rat= 1.2 (P95 = 1.33)  
    LD50Guinea pig/LD50Rat= 0.71  
    (P95 = 2.96) [68]
    LD50Cat/LD50Rat= 0.31 (P95 = 1.47)  
    LD50Rabbit/LD50Rat= 0.76 (P95 = 2.46)  
    LD50Monkey/LD50Rat= 0.63 (P95 = 0.88)  
    LD50Dog/LD50Rat= 0.82 (P95 = 4.87)  
216 pesticides NOAEL Mouse, rat, dog NOAELMouse/NOAELRat = 2.22 (P95 = 24.2)
NOAELRat/NOAELDog = 1.70 (P95 = 16.6)
[68]
    NOAELMouse/NOAELDog = 6.00 (P95 = 44.8)  
58 compounds NOAEL and Critical Effect Dose (CED) Mouse, rat NOAELMouse/NOAELRat : P95 = 15.5; GSD = 3.4 [74]
    CEDMouse /CEDRat : P95 = 5.6  
    Default value of 10 corresponds to 49th percentile and 71st percentile of mouse to human and rat to human distributions respectively