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Table 1 Distribution of the 182 genes by canonical pathways involved in the tobacco smoke metabolism

From: Selection of genes for gene-environment interaction studies: a candidate pathway-based strategy using asthma as an example

Canonical pathways

P-value*

N of genes

NRF2-mediated Oxidative Stress Response

1.58E-31

46

Glutathione Redox Reactions I

1.26E-25

16

Xenobiotic Metabolism Signaling

6.31E-22

44

Aryl Hydrocarbon Receptor Signaling

3.98E-21

32

Mitochondrial Dysfunction

6.31E-19

30

Glutathione-mediated Detoxification

2.00E-18

15

Production of Nitric Oxide and Reactive Oxygen Species in Macrophages

3.98E-16

31

Acute Phase Response Signaling

2.51E-14

28

Antioxidant Action of Vitamin C

1.58E-12

20

IL-8 Signaling

1.26E-11

26

Apoptosis Signaling

2.95E-09

16

Superpathway of Citrulline Metabolism

4.07E-08

7

Superoxide Radicals Degradation

1.05E-07

5

IL-6 Signaling

1.74E-07

16

iNOS Signaling

2.00E-07

10

VEGF Signaling

1.29E-06

13

fMLP Signaling in Neutrophils

1.95E-06

14

Chemokine Signaling

3.02E-06

11

VEGF Family Ligand-Receptor Interactions

5.50E-05

10

NF-KB Signaling

6.31E-05

15

CCR5 Signaling in Macrophages

1.10E-04

9

IL-17A Signaling in Airway Cells

3.89E-04

8

Nucleotide Excision Repair Pathway

4.07E-04

6

IL-1 Signaling

1.10E-03

9

Nicotine Degradation II

2.82E-03

6

Nicotine Degradation III

7.08E-03

5

CCR3 Signaling in Eosinophils

1.51E-02

8

eNOS Signaling

2.63E-02

8

  1. *P-values for pathway enrichment testing as calculated by IPA.