Table 1 Candidate genes that were examined for their associations with in utero arsenic exposure
Gene Symbol | RefSeq | Gene Name | Regulation by arsenic (biological system) [Reference] |
|---|---|---|---|
AKR1C3 | NM_003739 | aldo-keto reductase family 1, member C3 | Up-regulation (cell line) [24] |
ENPP2 | NM_001040092 | autotaxin | Up-regulation (cell line) [25] |
HMOX1 | NM_002133 | heme oxygenase 1 | Up-regulation (cell line) [26] |
LEP | NM_000230 | leptin | Up-regulation (placenta) [14] |
NFE2L2 | NM_001145413 | nuclear factor (erythroid-derived 2)-like 2 | Up-regulation (cell line) [27] |
TYMS | NM_001071 | thymidylate synthetase | Down-regulation (cell line, primary white blood cells) [28] |
AQP9 | NM_020980 | aquaporin 9 | Up-regulation (liver) [29] |
AS3MT | NM_020682 | arsenic (+3 oxidation state) methyltransferase | not available |
SLC39A2 | NM_014579 | solute carrier family 39, member 2 | not available |