Within-person reproducibility of urinary bisphenol A and phthalate metabolites over a 1 to 3 year period among women in the Nurses’ Health Studies: a prospective cohort study

Table 3 Urinary bisphenol A, phthalate metabolite, and phthalic acid excretion distributions after adjustment for creatinine levels

Analyte	Parent phthalate	Geometric mean		Median (5^th- 95^thpercentile)
Analyte	Parent phthalate	ng/mg creatinine	pmol/mg creatinine	ng/mg creatinine	pmol/mg creatinine
Bisphenol A	NA	2.8	12.1	2.7 (0.9 – 9.2)	12.0 (3.8 – 40.3)
Phthalate metabolite
MEP	DEP	135.9	700.7	140.5 (21.0 – 894.6)	724.2 (108.2 – 4611.2)
MiBP	DBP	3.6	16.1	3.5 (0.9 – 12.0)	15.6 (4.2 – 54.0)
MnBP	DBP	37.0	166.7	36.8 (10.4 – 177.0)	165.8 (46.7 – 797.4)
DBP metabolite sum^a	DBP		190.9		177.7 (52.8 – 1157.2)
MBzP	BzBP	16.1	62.8	14.3 (4.2 – 96.9)	55.7 (16.3 – 378.4)
MEHP	DEHP	5.8	20.8	5.1 (1.5 – 26.0)	18.5 (5.3 – 93.4)
MEHHP	DEHP	35.7	121.3	31.7 (8.7 – 162.8)	107.9 (29.5 – 553.8)
MEOHP	DEHP	30.7	105.0	25.6 (7.4 – 136.2)	87.7 (25.3 – 466.5)
MECPP	DEHP	46.3	150.4	42.5 (15.8 – 214.8)	137.9 (51.4 – 697.4)
DEHP metabolite sum^a	DEHP		421.4		361.7 (120.4 – 1520.5)
Total^b	NA		1681.3		1566.0 (415.5 – 8687.9)
Phthalic acid	NA	88.2	531.1	90.0 (38.5 – 196.1)	542.5 (232.2 – 1181.5)

Abbreviations: BzBP benzylbutyl phthalate, DBP dibutyl phthalates, DEHP di-2-ethylhexyl phthalate, DEP diethyl phthalate, MBzP monobenzyl phthalate, MECPP mono-(2-ethyl-5-carboxy-pentyl) phthalate, MEHHP mono-(2-ethyl-5-hydroxyhexyl) phthalate, MEHP mono-2-ethylhexyl phthalate, MEOHP mono-(2-ethyl-5-oxohexyl) phthalate, MEP monoethyl phthalate, MiBP monoisobutyl phthalate, MnBP mono-n-butyl phthalate, NA not applicable.
^aDBP metabolite sum = MiBP + MnBP; DEHP metabolite sum = MEHP + MEHHP + MEOHP + MECPP.
^bSum of 8 phthalate metabolites.

ISSN: 1476-069X