Statistical strategies for constructing health risk models with multiple pollutants and their interactions: possible choices and comparisons

Table 5 Results of model selection for the NHANES data (2005–2008)

Method	Response variable - Bilirubin		Response variable - GGT
Method	Main effects	Interactions	Main effects	Interactions
BMA	OP, EPAR, P8, MEOHP, MiBP	OPEPAR, OPMEOHP, P8MEOHP, MEOHPMiBP	EPAR, PPAR, MCPP, MEOHP, MiBP, 2,5-DCP	EPARPPAR, EPARMCPP, EPARMiBP, MEOHP2,5-DCP,
LASSO	OP, TCS, EPAR, P8, MCPP, MEOHP, MiBP	OPEPAR, OPMEOHP, TCSEPAR, TCSMCPP, EPARMCPP, P8MCPP	EPAR, PPAR, P8, MCPP, MEOHP, MiBP, 2,5-DCP, 2,4,5-TCP	EPARPPAR, EPARP8, EPARMCPP, EPARMiBP, EPAR2,5-DCP, PPAR2,4,5-TCP, P8MCPP, MCPP2,4,5-TCP, MiBP*2,4,5-TCP
SPCA	OP, EPAR, P8, MCPP, MEOHP, MiBP	OPP8, OPMEOHP, P8MCPP, P8MEOHP, P8*MiBP	EPAR, PPAR, P8, MCPP, MEOHP, MiBP, 2,5-DCP, 2,4,5-TCP	EPARPPAR, MCPP2,5-DCP, EPARMEOHP, EPARMiBP, EPAR2,5-DCP, P8MEOHP, MEOHP2,5-DCP, P82,5-DCP, EPAR*P8
DSA	OP, TCS, EPAR, P8, MCPP, MEOHP, MiBP	N/A	EPAR, PPAR, P8, MCPP, MEOHP, MiBP, 2,5-DCP, 2,4,5-TCP	N/A

Phthalates: MEHP, mono(2-ethylhexyl) phthalate; MEHHP, mono(2-ethyl-5-hydroxyhexyl) phthalate; MEOHP, mono(2-ethyl-5-oxohexyl) phthalate; MECPP, mono(2-ethyl-5-carboxypentyl) phthalate; MnBP, mono-n-butyl phthalate; MiBP, mono-isobutyl phthalate; MBzP, mono-benzyl phthalate; MEP, mono-ethyl phthalate; MCPP, mono(3-carboxypropyl) phthalate. Phenols: BPA, bisphenol-A; TCS, triclosan; BPAR, butyl paraben; EPAR, ethyl paraben; MPAR, methyl paraben; PPAR, propyl paraben; BP3, benzophenone-3; OP, 4-tert octylphenol. Pesticides: 2,5-DCP, 2,5-dichlorophenol; 2,4-DCP, 2,4-dichlorophenol; OPP, o-phenyl phenol; 2,4,5-TCP, 2,4,5-trichlorophenol; 2,4,6-TCP, 2,4,6-trichlorophenol. Perchlorate and related anions: P8, perchlorate; NO3, nitrate; SCN, thiocyanate.

ISSN: 1476-069X