Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in infants – a Dutch prospective cohort study

de Cock, Marijke; de Boer, Michiel R; Lamoree, Marja; Legler, Juliette; van de Bor, Margot

doi:10.1186/1476-069X-13-106

Environmental Health

Table 3 Regression coefficients for various exposures in boys (in quartiles) and T4 (nmol/L)

From: Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in infants – a Dutch prospective cohort study

	N	Q1	Q2		Q3		Q4
Compound			β (95% CI)	p-value	β (95% CI)	p-value	β (95% CI)	p-value
DDE (Total, ng/L)		<41.80	41.80 – 74.50		74.51 – 107.50		>107.50
Crude	70	Ref	-2.1 (-17.33, 13.23)	0.789	-8.5 (-23.51, 6.43)	0.258	2.1 (-12.27, 16.42)	0.773
Model A¹	65	Ref	-3.3 (-20.00, 13.33)	0.690	-6.6 (-22.60, 9.31)	0.407	2.8 (-12.05, 17.58)	0.710
Model B²	61	Ref	10.5 (-13.94, 34.90)	0.389	2.9 (-17.00, 22.71)	0.771	8.0 (-10.68, 26.77)	0.389
MECPP (ng/mL)		<0.22	0.22 – 0.27		0.28 – 0.38		>0.38
Crude	63	Ref	-1.8 (-18.34, 14.65)	0.823	-4.9 (-21.73, 12.00)	0.565	9.3 (-7.97, 26.63)	0.284
Model A¹	57	Ref	-3.2 (-21.01, 14.61)	0.719	-6.8 (-25.19, 11.50)	0.456	9.6 (-9.30, 28.56)	0.311
Model B²	52	Ref	-18.2 (-37.96, 1.62)	0.070	-12.3 (-34.98, 10.37)	0.257	-4.2 (-26.88, 18.51)	0.708
MEHHP (ng/mL)		<0.18	0.18 – 0.27		0.28 – 0.39		>0.39
Crude	63	Ref	-4.0 (-21.73, 13.73)	0.653	-3.1 (-22.87, 16.77)	0.758	2.7 (-16.20, 21.54)	0.777
Model A¹	57	Ref	-1.9 (-21.06, 17.23)	0.841	-1.7 (-22.42, 19.11)	0.873	7.8 (-12.74, 28.36)	0.448
Model B²	52	Ref	-2.4 (-26.23, 21.51)	0.841	1.3 (-24.08, 26.60)	0.919	4.6 (-22.28, 31.50)	0.728
MEOHP (ng/mL)		<0.17	0.17 – 0.23		0.24 – 0.41		>0.41
Crude	63	Ref	15.2 (-2.37, 32.71)	0.089	8.8 (-9.37, 26.97)	0.336	12.2 (-5.97, 30.37)	0.184
Model A¹	57	Ref	13.6 (-4.66, 31.95)	0.140	7.9 (-10.50, 26.30	0.392	15.9 (-2.98, 34.75)	0.097
Model B²	52	Ref	3.8 (-19.48, 27.16)	0.738	-6.1 (-31.51, 19.31)	0.626	-1.8 (-26.20, 22.58)	0.880
PFOS (ng/L)		<1026	1026 – 1600		1601 – 2175		>2175
Crude	62	Ref	-22.1^* (-38.75, -5.48)	0.010	-16.8^* (-33.47, -0.21)	0.047	-11.8 (-29.14, 5.64)	0.181
Model A¹	57	Ref	-22.8^* (-39.83, -5.83)	0.010	-18.0 (-36.84, 0.79)	0.060	-13.9 (-31.56, 3.81)	0.121
Model B²	52	Ref	-7.9 (-31.56, 15.74)	0.499	-16.5 (-40.32, 7.34)	0.167	-9.6 (-32.57, 13.31)	0.396
PFOA (ng/L)		<591	591 – 865		866 – 1200		>1200
Crude	62	Ref	-20.3^* (-37.29, -3.24)	0.021	-12.2 (-27.15, 2.80)	0.109	-11.3 (-28.29, 5.80)	0.190
Model A¹	57	Ref	-16.8 (-35.09, 1.54)	0.072	-7.7 (-23.93, 8.46)	0.341	-9.2 (-27.09, 8.79)	0.310
Model B²	52	Ref	7.9 (-18.04, 33.92)	0.536	-2.1 (-20.94, 16.78)	0.823	6.2 (-16.08, 28.50)	0.572

¹Adjusted for thyroid gland problems, use of thyroid medication, and birth weight. Caesarean section was constant and not included in the model.
²Model A + additionally adjusted for gestational weight gain, gestational age, parity, smoking, alcohol, maternal BMI, and maternal age at birth.
^*p < 0.050.

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ISSN: 1476-069X

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