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Table 3 Fecundability ratios according to female serum concentrations of PFAS

From: Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine

   PFOA PFOS PFHxS PFNA
Greenland N FR (95% CI) FR (95% CI) FR (95% CI) FR (95% CI)
 Low 150 1 (Reference) 1 (Reference) 1 (Reference) 1 (Reference)
 Medium 149 0.95 (0.72, 1.26) 0.80 (0.60, 1.05) 1.05 (0.79, 1.38) 0.76 (0.58, 1.00)
 High 149 0.87 (0.65, 1.18) 0.80 (0.60, 1.05) 0.90 (0.68, 1.19) 0.71 (0.54, 0.94)
 Continuous log-scale 448 0.97 (0.73, 1.27) 0.83 (0.64, 1.07) 0.97 (0.78, 1.20) 0.72 (0.58, 0.89)
Poland      
 Low 68 1 (Reference) 1 (Reference) 1 (Reference) 1 (Reference)
 Medium 68 0.94 (0.62, 1.42) 0.87 (0.57, 1.33) 0.86 (0.57, 1.30) 0.94 (0.62, 1.41)
 High 67 1.08 (0.71, 1.64) 0.90 (0.60, 1.37) 0.94 (0.62, 1.42) 1.31 (0.87, 1.98)
 Continuous log-scale 203 1.21 (0.79, 1.84) 0.94 (0.58, 1.50) 0.90 (0.65, 1.24) 1.35 (0.93, 1.95)
Ukraine      
 Low 96 1 (Reference) 1 (Reference) 1 (Reference) 1 (Reference)
 Medium 96 1.12 (0.78, 1.59) 0.89 (0.62, 1.27) 0.85 (0.59, 1.23) 0.79 (0.55, 1.12)
 High 95 1.04 (0.72, 1.51) 0.93 (0.64, 1.34) 1.11 (0.78, 1.58) 0.88 (0.62, 1.26)
 Continuous log-scale 287 1.20 (0.87, 1.67) 1.06 (0.78, 1.45) 1.05 (0.84, 1.31) 0.74 (0.53, 1.04)
Pooled sample      
Continuous log-scale 938 1.04 (0.87, 1.25) 0.90 (0.76, 1.07) 0.97 (0.85, 1.11) 0.80 (0.69, 0.94)
  1. FRs are presented in country-specific tertiles and according to a continuous logarithm-transformed scale.
  2. CI confidence intervals, FR fecundability ratio, N number of women, PFAS perfluoroalkyl substances.
  3. The FR analyses are adjusted for parity, gestational week of blood sampling, smoking status, maternal age and BMI. In addition the pooled analysis is adjusted for country.